Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration.

Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration. Research Abstract Details 

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Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration. Abstract Text:

F C Schmitt,A L Gomes,F Milanezi,R Reis,R H Bardales,F C Schmitt,A L Gomes,F Milanezi,R Reis,R H Bardales,F C Schmitt,A L Gomes,F Milanezi,R Reis,R H Bardales,F C Schmitt,A L Gomes,F Milanezi,R Reis,R H Bardales,

Gastrointestinal stromal tumors (GISTs) are characterized by overexpression and mutations of c-Kit. Approximately 80% of c-Kit mutations occur in exon 11, being a response factor to imatinib (Gleevec) therapy. We aimed to assess whether c-Kit and PDGFRA mutation analysis of GISTs obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) could be routinely performed. Mutation analysis of c-Kit hotspot exons (9, 11, 13 and 17) and PDGFRA hotspot exons (12 and 18) was performed in aspirates 51 mesenchymal tumors. We identified c-Kit mutations in 61% of GIST cases, in accordance with previously published ranges (30-90%). Nearly 95% (19/20) of c-kit-mutant tumors carried exon 11 mutations. Mutation analysis is possible in FNA cell blocks and can assist in the diagnosis and therapeutic decisions in GIST cases.

Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration. Publishing Authors By Initials

FC Schmitt,AL Gomes,F Milanezi,R Reis,RH Bardales,FC Schmitt,AL Gomes,F Milanezi,R Reis,RH Bardales,FC Schmitt,AL Gomes,F Milanezi,R Reis,RH Bardales,FC Schmitt,AL Gomes,F Milanezi,R Reis,RH Bardales,

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Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Minerva medica

VOLUME: 98

Page Numbers: 385-8

Journal Abbreviation: Minerva Med.

ISSN: 0026-4806

DAY: 8

MONTH: Aug

YEAR: 2007

Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration. Information

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LANGUAGE: eng

NlmUniqueID: 400732

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AFFILIATION: IPATIMUP and Medical Faculty of Porto University, Porto, Portugal, fernando.schmitt@ipatimup.pt.

Country: Italy

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MEDLINETA: Minerva Med

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