Mutational bias for body size in rhabditid nematodes.

Mutational bias for body size in rhabditid nematodes. Research Abstract Details 

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Mutational bias for body size in rhabditid nematodes. Abstract Text:

Dejerianne Ostrow,Naomi Phillips, Avalos,Dustin Blanton,Ashley Boggs,Thomas Keller,Laura Levy,Jeffrey Rosenbloom,Charles F Baer,

Mutational bias is a potentially important agent of evolution, but it is difficult to disentangle the effects of mutation from those of natural selection. Mutation-accumulation experiments, in which mutations are allowed to accumulate at very small population size, thus minimizing the efficiency of natural selection, are the best way to separate the effects of mutation from those of selection. Body size varies greatly among species of nematode in the family rhabditidae; mutational biases are both a potential cause and a consequence of that variation. We report data on the cumulative effects of mutations that affect body size in three species of rhabditid nematode that vary fivefold in adult size. Results are very consistent with previous studies of mutations underlying fitness in the same strains: two strains of Caenorhabditis briggsae decline in body size about twice as fast as two strains of C. elegans, with a concomitant higher point estimate of the genomic mutation rate; the confamilial Oscheius myriophila is intermediate. There is an overall mutational bias, such that mutations reduce size on average, but the bias appears consistent between species. The genetic correlation between mutations that affect size and those underlying fitness is large and positive, on average.

Mutational bias for body size in rhabditid nematodes. Publishing Authors By Initials

D Ostrow,N Phillips,A Avalos,D Blanton,A Boggs,T Keller,L Levy,J Rosenbloom,CF Baer,

For similar genetic processes: selection (genetics) research abstracts see: genetic processes: selection (genetics) research

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Mutational bias for body size in rhabditid nematodes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genetics

VOLUME: 176

Page Numbers: 1653-61

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 4

MONTH: 05

YEAR: 2007

Mutational bias for body size in rhabditid nematodes. Information

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LANGUAGE: eng

NlmUniqueID: 374636

Mutational bias for body size in rhabditid nematodes. Keywords Mesh Terms:

KEYWORDS: Selection (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Mutational bias for body size in rhabditid nematodes.

AFFILIATION: Department of Zoology, University of Florida, Gainesville, Florida 32611-8525, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM36827

ACRONYM: GM

MEDLINETA: Genetics

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