Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization.

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Research Abstract Details 

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Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Abstract Text:

Michael J Ciancanelli,Christopher F Basler,

Matrix (M) proteins reportedly direct the budding of paramyxoviruses from infected cells. In order to begin to characterize the assembly process for the highly lethal, emerging paramyxovirus Nipah virus (NiV), we have examined the budding of NiV M. We demonstrated that expression of the NiV M protein is sufficient to produce budding virus-like particles (VLPs) that are physically and morphologically similar to NiV. We identified in NiV M a sequence, YMYL, with similarity to the YPDL late domain found in the equine infectious anemia virus Gag protein. When the YMYL within NiV M was mutated, VLP release was abolished and M was relocalized to the nucleus, but the mutant M proteins retained oligomerization activity. When YMYL was fused to a late-domain mutant of the Ebola virus VP40 matrix protein, VP40 budding was restored. These results suggest that the YMYL sequence may act as a trafficking signal and a late domain for NiV M.

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Publishing Authors By Initials

MJ Ciancanelli,CF Basler,

For similar viruses: virion research abstracts see: viruses: virion research

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Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of virology

VOLUME: 80

Page Numbers: 12070-8

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 27

MONTH: 09

YEAR: 2006

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Keywords Mesh Terms:

KEYWORDS: Virion

MESH TERMS: physiology

Chemical & Substance for Abstract: Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. Information

Substance Name: Viral Matrix Proteins

Registry Number: 0

Grant and Affiliation Information for Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization.

AFFILIATION: Department of Microbiology, Box 1124, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI057158

ACRONYM: AI

MEDLINETA: J Virol

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