Mutagen sensitivity: a genetic predisposition factor for cancer.

Mutagen sensitivity: a genetic predisposition factor for cancer. Research Abstract Details 

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Mutagen sensitivity: a genetic predisposition factor for cancer. Abstract Text:

Xifeng Wu,Jian Gu,Margaret R Spitz,

Mutagen sensitivity, measured by quantifying the chromatid breaks induced by mutagens in short-term cultures of peripheral blood lymphocytes, has been used as an indirect measure of DNA repair capacity. Numerous epidemiologic studies have suggested that mutagen sensitivity is a cancer susceptibility factor for a variety of epithelial cancers. A recent classic twin study examined systematically the role of genetic and environmental factors on the mutagen sensitivity phenotype and provided compelling evidence that mutagen sensitivity is highly heritable. A new prospective analysis provides further support to the notion that mutagen sensitivity increases the risk of cancer. In this review, we briefly summarize nearly two decades of epidemiologic and genetic studies linking mutagen sensitivity and cancer risk. The evidence is becoming increasingly convincing that mutagen sensitivity is a risk factor for cancer development.

Mutagen sensitivity: a genetic predisposition factor for cancer. Publishing Authors By Initials

X Wu,J Gu,MR Spitz,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Mutagen sensitivity: a genetic predisposition factor for cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer research

VOLUME: 67

Page Numbers: 3493-5

Journal Abbreviation:

ISSN: 0008-5472

DAY: 15

MONTH: Apr

YEAR: 2007

Mutagen sensitivity: a genetic predisposition factor for cancer. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

Mutagen sensitivity: a genetic predisposition factor for cancer. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Mutagen sensitivity: a genetic predisposition factor for cancer. Information

Substance Name: Mutagens

Registry Number: 0

Grant and Affiliation Information for Mutagen sensitivity: a genetic predisposition factor for cancer.

AFFILIATION: Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA. xwu@mdanderson.org

Country: United States

AGENCY: United States NCI

GRANT: CA 098897

ACRONYM: CA

MEDLINETA: Cancer Res

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