Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation.

Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation. Research Abstract Details 

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Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation. Abstract Text:

ABSTRACT A modified alkalizing supplementation (MAS) was tested on skeletal muscle metabolism in aged rats undergoing exhaustive exercise. Aged Wistar rats were allocated into two groups: saline (A) and saline added with 16 mg of MAS (B) before treadmill exercise. Blood and gastrocnemius and soleus muscle were analyzed after exercise for succinate dehydrogenase (SDH), acetylcarnitine (ALCAR), and glycogen. Lactic acid (LA), creatin-phosphokinase (CPK), and gas analysis were tested in the blood. Exercise caused a significant increase of LA and CPK and muscle glycogen fall. Arterial desaturation at exhaustion was prevented in the B group (p < 0.05). Exercise-induced increase of SDH and ALCAR was further enhanced in B rats (p < 0.05). This study suggests that MAS can improve fast and endurance muscle metabolism in aged rats by increasing cellular acetyl group availability and tricarboxylic acid turnover.

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Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Rejuvenation research

VOLUME: 11

Page Numbers: 519-22

Journal Abbreviation: Rejuvenation Res

ISSN: 1549-1684

DAY: 29

MONTH: Apr

YEAR: 2008

Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation. Information

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LANGUAGE: eng

NlmUniqueID: 101213381

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Grant and Affiliation Information for Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation.

AFFILIATION: GAIA Age-Management Foundation, Pavia, Italy.

Country: United States

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MEDLINETA: Rejuvenation Res

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