Muscle respiratory chain enzyme activities in parkinson's disease and in multisystem extrapyramidal disorders with parkinsonism as the main clinical feature.

Muscle respiratory chain enzyme activities in parkinson's disease and in multisystem extrapyramidal disorders with parkinsonism as the main clinical feature. Research Abstract Details 

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Muscle respiratory chain enzyme activities in parkinson's disease and in multisystem extrapyramidal disorders with parkinsonism as the main clinical feature. Abstract Text:

A primary mitochondrial dysfunction has been recently hypothesized in the pathogenesis of Parkinson's disease (PD). As a matter of fact, MPTP (a drug able to induce neuronal loss in substantia nigra) is a specific inhibitor of Complex I, while controversial data on Complex I deficiency have been reported in platelets, muscle and brain of patients affected by Parkinson's disease. Here we report data on respiratory chain enzyme activities in isolated muscle mitochondria from 6 patients with classical PD (two with the hereditary form, HPD), and in 6 patients with a multisystem extrapyramidal disorder (MSED) with parkinsonsim as the main clinical feature. While histological and biochemical evidence of mitochondrial dysfunction has been detected in 1 case with PD and in 3 cases with MSED, normal results have been obtained in the other cases confirming the extreme clinical and biochemical heterogeneity of these disorders.

Muscle respiratory chain enzyme activities in parkinson's disease and in multisystem extrapyramidal disorders with parkinsonism as the main clinical feature. Publishing Authors By Initials

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Muscle respiratory chain enzyme activities in parkinson's disease and in multisystem extrapyramidal disorders with parkinsonism as the main clinical feature. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of gerontology and geriatrics

VOLUME: 19 Suppl 1

Page Numbers: 155-61

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ISSN: 0167-4943

DAY: 24

MONTH: 07

YEAR: 1994

Muscle respiratory chain enzyme activities in parkinson's disease and in multisystem extrapyramidal disorders with parkinsonism as the main clinical feature. Information

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LANGUAGE: eng

NlmUniqueID: 8214379

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Country: Netherlands

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MEDLINETA: Arch Gerontol Geriatr

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