Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy.

Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy. Research Abstract Details 

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Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy. Abstract Text:

H Okuma,D Kurita,T Ohnuki,M Haida,Y Shinohara,H Okuma,D Kurita,T Ohnuki,M Haida,Y Shinohara,

Simultaneous measurements of muscle energy metabolism using (31)P-magnetic resonance spectroscopy ((31)P-MRS) and the kinetics of muscular oxygen metabolism using near-infrared spectroscopy (NIRS) were conducted in polymyositis (PM) patients. The subjects were 12 PM patients (age 45 +/- 12 years) and 12 normal controls (age 41 +/- 12 years). The muscle phosphocreatine (PCr) index and intracellular pH (pHi) were determined with (31)P-MRS and the changes in intramuscular oxygenated (oxy-Hb), deoxygenated (deoxy-Hb), and total haemoglobin (total Hb) were evaluated with NIRS . The pHi and PCr index before steroid therapy in PM patients were significantly lower during exercise than in normal controls, and their recovery was statistically significantly delayed compared with the controls. The pattern of changes in NIRS over time before steroid therapy in PM patients differed from that in normal controls. There were smaller changes in deoxy-Hb and oxy-Hb during exercise, and total Hb decreased during exercise. In contrast, the kinetics of muscular metabolism after steroid therapy showed changes similar to those seen in normal controls. Simultaneous (31)P-MRS and NIRS measurements to determine the kinetics of muscular metabolism are expected to be useful as a noninvasive approach for the evaluation of treatment effects in PM patients.

Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy. Publishing Authors By Initials

H Okuma,D Kurita,T Ohnuki,M Haida,Y Shinohara,H Okuma,D Kurita,T Ohnuki,M Haida,Y Shinohara,

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Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of clinical practice

VOLUME: 61

Page Numbers: 684-9

Journal Abbreviation: Int. J. Clin. Pract.

ISSN: 1368-5031

DAY: 3

MONTH: 08

YEAR: 2006

Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy. Information

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LANGUAGE: eng

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AFFILIATION: Department of Neurology, Tokai University Tokyo Hospital, Japan. ookuma@tok.u-tokai.ac.jp

Country: England

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MEDLINETA: Int J Clin Pract

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