Muscle-derived stem cells for tissue engineering and regenerative therapy.

Muscle-derived stem cells for tissue engineering and regenerative therapy. Research Abstract Details 

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Muscle-derived stem cells for tissue engineering and regenerative therapy. Abstract Text:

Arvydas Usas,Johnny Huard,Arvydas Usas,Johnny Huard,

Skeletal muscle has been recognized as an essential source of progenitor or satellite cells, which are primarily responsible for muscle regeneration. Recently, muscle has also been identified as a valuable source of postnatal stem cells that appear to be distinct from satellite cells and possess the ability to differentiate into other cell lineages. These cells, named muscle-derived stem cells, possess a high myogenic capacity and effectively regenerate both skeletal and cardiac muscle. Remarkably, when genetically modified ex vivo to express growth factors, these cells can differentiate into osteogenic and chondrogenic lineages and have been shown to promote the repair of bone and cartilage. Muscle stem cell-based regenerative therapy and tissue engineering using ex vivo gene therapy, are promising approaches for the treatment of various musculoskeletal, cardiovascular, and urological disorders.

Muscle-derived stem cells for tissue engineering and regenerative therapy. Publishing Authors By Initials

A Usas,J Huard,A Usas,J Huard,

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Muscle-derived stem cells for tissue engineering and regenerative therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomaterials

VOLUME: 28

Page Numbers: 5401-6

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 26

MONTH: Dec

YEAR: 2007

Muscle-derived stem cells for tissue engineering and regenerative therapy. Information

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LANGUAGE: eng

NlmUniqueID: 8100316

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Grant and Affiliation Information for Muscle-derived stem cells for tissue engineering and regenerative therapy.

AFFILIATION: Stem Cell Research Center, Children's Hospital of Pittsburgh, Department of Orthopedic Surgery, Pittsburgh, PA 15213, USA.

Country: England

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MEDLINETA: Biomaterials

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