Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds.

Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds. Research Abstract Details 

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Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds. Abstract Text:

Haixiang Zhang,Zhixian He,Yunfang Gao,Helmut G Hinghofer-Szalkay,Xiaoli Fan,Haixiang Zhang,Zhixian He,Yunfang Gao,Helmut G Hinghofer-Szalkay,Xiaoli Fan,

AIM: We studied the potential of two herbal compounds (HC-1 and HC-2) in different dosages (HC-1, containing ligustrazine; HC-2, containing radix astragali) as a countermeasure against muscle atrophy in a hindlimb unloading rat model. Soleus muscle weight, fiber type distribution, cross-sectional area (CSA), and myosin ATPase activity were measured. METHODS: Six rats each were assigned to a nine-group design: Control (CON); hindlimb unloading only (HLU); hindlimb unloading plus intragastric water instillation (HLU-W); and hindlimb unloading plus different dosages of instilled HC-1 (HLU-HC-1l, HLU-HC-1m, HLU-HC-1h) or HC-2 (HLU-HC-2l, HLU-HC-2m, HLU-HC-2h). RESULTS: As expected, in HLU and HLU-W, soleus muscle-to-body weight ratio and CSA of type I and II fiber went down, and myosin ATPase activity and the percentage of type II fibers went up, all compared with CON. Compared to untreated rats, high-dose HC-1 enhanced type I and II fiber CSA by 77% and 55%, respectively; myosin ATPase activity (type II fiber percentage) were lower, but soleus muscle-to-body weight ratio did not change. High-dose HC-2 enhanced soleus muscle-to-body weight ratio by 33%; and type I / type II fiber CSA by 143% and 83% above HLU-W values, respectively, and resulted in a slower myosin ATPase activity (corresponding to a lower type II fiber percentage). Low- to mid-dose HC-1 and HC-2 showed some preventive effects as well. CONCLUSION: HC-1 and HC-2 in proper dosages diminished muscle atrophy that otherwise occurs in simulated weightlessness.

Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds. Publishing Authors By Initials

H Zhang,Z He,Y Gao,HG Hinghofer-Szalkay,X Fan,H Zhang,Z He,Y Gao,HG Hinghofer-Szalkay,X Fan,

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Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Aviation, space, and environmental medicine

VOLUME: 78

Page Numbers: 926-31

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ISSN: 0095-6562

DAY: 24

MONTH: Oct

YEAR: 2007

Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds.

AFFILIATION: College of Life Sciences, Northwest University, Xi'an, China.

Country: United States

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MEDLINETA: Aviat Space Environ Med

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