Muscle characteristics in effort angina before and after CABG.

Muscle characteristics in effort angina before and after CABG. Research Abstract Details 

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Muscle characteristics in effort angina before and after CABG. Abstract Text:

J Karlsson,L Lin,S Gunnes,C ,H ,E Jansson,B Semb,

Seven males with effort angina undertook graded ergometer tests and had muscle biopsies taken from their vastus lateralis muscle before, and three and six months after coronary bypass surgery. Muscle fibre composition (percentage of slow twitch fibres), ubiquinone (vitamin Q), and oxidative and fermentative enzyme activities were determined. After six months, muscle ubiquinone and oxidative enzymes were still depressed, indicating sustained muscle trauma. The only peripheral changes were that muscle lactate dehydrogenase and its skeletal muscle-specific subunits and isozymes were increased 35% to 40% (P < 0.001) three to six months postsurgery. Onset of blood lactate accumulation (2.0 mmol/L), symptom-limited ('maximal') exercise and peak blood lactate increased linearly over time (r = 0.52, P < 0.05; r = 0.63, P < 0.01; and r = 0.76, P < 0.001, respectively). It is suggested that the initial physical performance increase was due to improved circulatory capacity, oxygen delivery and lactate efflux, whereas the increased fermentative capacity ('anaerobic power') first contributed after a lag of three or more months. Whether the muscle histochemical changes reflected a healing process (recovery) is speculative.

Muscle characteristics in effort angina before and after CABG. Publishing Authors By Initials

J Karlsson,L Lin,S Gunnes,C ,H ,E Jansson,B Semb,

For similar organic chemicals: quinones: benzoquinones: ubiquinone research abstracts see: organic chemicals: quinones: benzoquinones: ubiquinone research

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Muscle characteristics in effort angina before and after CABG. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Canadian journal of cardiology

VOLUME: 13

Page Numbers: 577-82

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Jun

YEAR: 1997

Muscle characteristics in effort angina before and after CABG. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8510280

Muscle characteristics in effort angina before and after CABG. Keywords Mesh Terms:

KEYWORDS: Ubiquinone

MESH TERMS: metabolism

Chemical & Substance for Abstract: Muscle characteristics in effort angina before and after CABG. Information

Substance Name: Citrate (si)-Synthase

Registry Number: EC 2.3.3.1

Grant and Affiliation Information for Muscle characteristics in effort angina before and after CABG.

AFFILIATION: OBLA AB, Vaxholm, Sweden.

Country: CANADA

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MEDLINETA: Can J Cardiol

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