Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node.

Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Research Abstract Details 

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Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Abstract Text:

Y Habuchi,H Tanaka,T Yamamoto,M Nishio,J Morikawa,M Yoshimura,

Effects of acetylcholine (ACh) on the L-type calcium current were examined in isolated atrioventricular nodal cells that exhibited spontaneous contractions. ACh (0.1 to 10 microM) inhibited basal calcium current dose-dependently. This inhibition was eliminated by dialysis with 8Br cAMP or cAMP-dependent kinase inhibitory peptide. Both extracellular N-ethylmaleimide 50 microM and intracellular GDPssS 0.2 mM abolished the ACh effect. Dialysis with cGMP or NG-monomethyl-L-arginine did not significantly affect ACh inhibition of basal calcium current. Similarly, cGMP-dependent protein kinase inhibitor KT5823 (1 microM) and the type II phosphodiesterase inhibitor erythro-9-(2-hydroxy-3-nonyl) adenine (30 microM) did not attenuate the ACh effect. Therefore, ACh inhibits the basal calcium current in the atrioventricular node mainly by suppressing cAMP synthesis through the inhibitory GTP-binding protein.

Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Publishing Authors By Initials

Y Habuchi,H Tanaka,T Yamamoto,M Nishio,J Morikawa,M Yoshimura,

For similar cardiovascular system: heart: heart conduction system: sinoatrial node research abstracts see: cardiovascular system: heart: heart conduction system: sinoatrial node research

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Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Canadian journal of cardiology

VOLUME: 13

Page Numbers: 1188-90

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Dec

YEAR: 1997

Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Information

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LANGUAGE: eng

NlmUniqueID: 8510280

Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Keywords Mesh Terms:

KEYWORDS: Sinoatrial Node

MESH TERMS: physiology

Chemical & Substance for Abstract: Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node. Information

Substance Name: Acetylcholine

Registry Number: 51-84-3

Grant and Affiliation Information for Muscarinic inhibition of basal L-type calcium current in pacemaker cells from the rabbit atrioventricular node.

AFFILIATION: Department of Laboratory Medicine, Kyoto Prefectural University of Medicine, Japan. yhabuchi@koto.kpu-m.ac.jp

Country: CANADA

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MEDLINETA: Can J Cardiol

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