Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.

Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Research Abstract Details 

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Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Abstract Text:

Nadine De Albuquerque,Ehtesham Baig,Xuezhong Ma,Jianhua Zhang,William He,Andrea Rowe,Marlena Habal,Mingfeng Liu,Itay Shalev,Gregory P Downey,Reginald Gorczynski,Jagdish Butany,Julian Leibowitz,Susan R Weiss,Ian D McGilvray,M James Phillips,Eleanor N Fish,Gary A Levy,

Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. Intranasal infection of A/J mice with the coronavirus murine hepatitis virus strain 1 (MHV-1) produced pulmonary pathological features of SARS. All MHV-1-infected A/J mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death of all animals. In contrast, other mouse strains developed only mild transitory disease. Infected A/J mice had significantly higher cytokine levels, particularly macrophage chemoattractant protein 1 (MCP-1/CCL-2), gamma interferon, and tumor necrosis factor alpha. Furthermore, FGL2/fibroleukin mRNA transcripts and protein and fibrin deposits were markedly increased in the lungs of infected A/J mice. These animals developed a less robust type I interferon response to MHV-1 infection than resistant C57BL/6J mice, and treatment with recombinant beta interferon improved survival. This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies.

Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Publishing Authors By Initials

N De Albuquerque,E Baig,X Ma,J Zhang,W He,A Rowe,M Habal,M Liu,I Shalev,GP Downey,R Gorczynski,J Butany,J Leibowitz,SR Weiss,ID McGilvray,MJ Phillips,EN Fish,GA Levy,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

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Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 80

Page Numbers: 10382-94

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 3

MONTH: Nov

YEAR: 2006

Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: pathology

Chemical & Substance for Abstract: Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Information

Substance Name: Interferons

Registry Number: 9008-11-1

Grant and Affiliation Information for Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.

AFFILIATION: Toronto General Hospital, 585 University Ave., NCSB-11-1236, Toronto, Ontario M5G 2N2, Canada.

Country: United States

AGENCY: United States NIAID

GRANT: AI62817

ACRONYM: AI

MEDLINETA: J Virol

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