Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease.

Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. Research Abstract Details 

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Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. Abstract Text:

Human and murine stromal progenitor cells (SPCs) can suppress alloresponse in vitro, suggesting that SPCs may have clinical application toward prevention or treatment of graft-versus-host disease (GVHD). However, th eresults of in vivo studies have been conflicting. This study utilized an established murine model of acute GVHD to assess the ability of bone marrow derived murine SPCs (mSPCs) to prevent or treat GVHD. GVHD was established by transplantation of B6 bone marrow and spleen cells into lethally irradiated (900 cGy) B6 x BALB/c F(1) recipients. mSPCs were administered using various dose and timing protocols designed to either prevent or treat GVHD. After transplantation, mice were monitored daily for weight and survival. Differences in symptom severity were compared using a clinical GVHD scoring system. All GVHD control mice died of lethal GVHD. All groups treated with mSPCs for the prevention of GVHD went on to develop clinical GVHD with no alteration of the disease course or severity compared to controls. Administration of mSPC after the development of GVHD failed to improve the disease course. We conclude that in this model, the ability of SPCs to suppress alloresponse in vitro does not correlate with in vivo prevention or treatment of acute GVHD.

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Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: British journal of haematology

VOLUME: 141

Page Numbers: 224-34

Journal Abbreviation: Br. J. Haematol.

ISSN: 1365-2141

DAY: 3

MONTH: 03

YEAR: 2008

Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. Information

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LANGUAGE: eng

NlmUniqueID: 372544

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Grant and Affiliation Information for Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease.

AFFILIATION: The Children's Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL73253-01

ACRONYM: HL

MEDLINETA: Br J Haematol

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