Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model.

Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Research Abstract Details 

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Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Abstract Text:

Francesco Amato,Carlo Cosentino,Sabrina Pricl,Marco Ferrone,Maurizio Fermeglia,Mark Ming-Cheng Cheng,Robert Walczak,Mauro Ferrari,

Transport and surface interactions of proteins in nanopore membranes play a key role in many processes of biomedical importance. Although the use of porous materials provides a large surface-to-volume ratio, the efficiency of the operations is often determined by transport behavior, and this is complicated by the fact that transport paths (i.e., the pores) are frequently of molecular dimensions. Under these conditions, a protein diffusion can be slower than predicted from Fick law. The main contribution of this paper is the development of a mathematical model of this phenomenon, whose parameters are computed via molecular modeling, as described Part 1. Our multiscale modeling methodology, validated by using experimental results related to the diffusion of lysozyme molecules, constitutes an "ab initio" recipe, for which no experimental data are needed to predict the protein release, and can be tailored in principle to match any different protein and any different surface, thus filling gap between the nano and the macroscale.

Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Publishing Authors By Initials

F Amato,C Cosentino,S Pricl,M Ferrone,M Fermeglia,MM Cheng,R Walczak,M Ferrari,

For similar inorganic chemicals: elements: silicon research abstracts see: inorganic chemicals: elements: silicon research

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Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomedical microdevices

VOLUME: 8

Page Numbers: 291-8

Journal Abbreviation:

ISSN: 1387-2176

DAY: 3

MONTH: Dec

YEAR: 2006

Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Information

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LANGUAGE: eng

NlmUniqueID: 100887374

Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Keywords Mesh Terms:

KEYWORDS: Silicon

MESH TERMS: chemistry

Chemical & Substance for Abstract: Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model. Information

Substance Name: Muramidase

Registry Number: EC 3.2.1.17

Grant and Affiliation Information for Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model.

AFFILIATION: Department of Experimental and Clinical Medicine, Università degli Studi Magna Graecia, via T. Campanella 115, 88100 Catanzaro, Italy.

Country: United States

AGENCY: United States NCI

GRANT: N01-CO-12400

ACRONYM: CO

MEDLINETA: Biomed Microdevices

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