Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice.

Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Research Abstract Details 

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Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Abstract Text:

Satoshi Takahashi,Toshihiko Kawamura,Yasuhiro Kanda,Tomoyo Taniguchi,Tetsuro Nishizawa,Tsuneo Iiai,Katsuyoshi Hatakeyama,Toru Abo,Satoshi Takahashi,Toshihiko Kawamura,Yasuhiro Kanda,Tomoyo Taniguchi,Tetsuro Nishizawa,Tsuneo Iiai,Katsuyoshi Hatakeyama,Toru Abo,

Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T-cell lineage from thymus-derived cells (i.e. alphabetaTCR(high) cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mouse model of colitis induced by dextran sulphate sodium (DSS). Although the major site of the inflammation induced by DSS is known to be the large intestine, the small intestine was also damaged. When mice developed DSS-induced colitis, CD3+CD8+B220+ gammadelta T cells increased in PP in the small intestine. These gammadelta T cells, which are not seen in the PP of normal mice, resembled intraepithelial lymphocytes (IEL) in the small intestine in terms of their expression of CD5, CD103 and Thy1.2. In addition, the Vgamma/delta repertoire of these gammadelta T cells was similar to that of gammadelta IEL. When DSS-treated mice were injected with IEL isolated from normal mice, IEL including gammadelta T cells preferentially migrated to PP, raising the possibility that B220+ T cells seen in PP of diseased mice may derive from IEL in the small intestine. Our present study suggests that PP might be able to accept T-cell lineages from intestinal IEL as well as from thymus-derived T cells.

Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Publishing Authors By Initials

S Takahashi,T Kawamura,Y Kanda,T Taniguchi,T Nishizawa,T Iiai,K Hatakeyama,T Abo,S Takahashi,T Kawamura,Y Kanda,T Taniguchi,T Nishizawa,T Iiai,K Hatakeyama,T Abo,

For similar tissues: lymphoid tissue: thymus gland research abstracts see: tissues: lymphoid tissue: thymus gland research

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Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunology and cell biology

VOLUME: 83

Page Numbers: 504-10

Journal Abbreviation: Immunol. Cell Biol.

ISSN: 0818-9641

DAY: 3

MONTH: Oct

YEAR: 2005

Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Information

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LANGUAGE: eng

NlmUniqueID: 8706300

Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Keywords Mesh Terms:

KEYWORDS: Thymus Gland

MESH TERMS: immunology

Chemical & Substance for Abstract: Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice. Information

Substance Name: Dextran Sulfate

Registry Number: 9042-14-2

Grant and Affiliation Information for Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice.

AFFILIATION: Department of Immunology, Niigata University School of Medicine, Niigata, Japan.

Country: Australia

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MEDLINETA: Immunol Cell Biol

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