Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size.

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Abstract Text:

Theo H E Meuwissen,Mike E Goddard,Theo H E Meuwissen,Mike E Goddard,

A novel multipoint method, based on an approximate coalescence approach, to analyze multiple linked markers is presented. Unlike other approximate coalescence methods, it considers all markers simultaneously but only two haplotypes at a time. We demonstrate the use of this method for linkage disequilibrium (LD) mapping of QTL and estimation of effective population size. The method estimates identity-by-descent (IBD) probabilities between pairs of marker haplotypes. Both LD and combined linkage and LD mapping rely on such IBD probabilities. The method is approximate in that it considers only the information on a pair of haplotypes, whereas a full modeling of the coalescence process would simultaneously consider all haplotypes. However, full coalescence modeling is computationally feasible only for few linked markers. Using simulations of the coalescence process, the method is shown to give almost unbiased estimates of the effective population size. Compared to direct marker and haplotype association analyses, IBD-based QTL mapping showed clearly a higher power to detect a QTL and a more realistic confidence interval for its position. The modeling of LD could be extended to estimate other LD-related parameters such as recombination rates.

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Publishing Authors By Initials

TH Meuwissen,ME Goddard,TH Meuwissen,ME Goddard,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genetics

VOLUME: 176

Page Numbers: 2551-60

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 11

MONTH: 06

YEAR: 2007

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size.

AFFILIATION: IHA, Norwegian Academy of Life Sciences, 1432 As, Norway. theo.meuwissen@umb.no

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Genetics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size Related Publications

• An electrochemical color-switchable RGB dye: tristable [2]catenane.
• An extended hybrid density functional (X3LYP) with improved descriptions of nonbond interactions and thermodynamic properties of molecular systems.
• Copolymerization studies of vinyl chloride and vinyl acetate with ethylene using a transition-metal catalyst.
• Dendritic anion hosts: perchlorate uptake by G5-NH2 poly(propyleneimine) dendrimer in water and model electrolyte solutions.
• Dynamic transition in the structure of an energetic crystal during chemical reactions at shock front prior to detonation.
• Effect of acute paracetamol overdose on changes in serum and urine electrolytes.
• Effect of heat upon the nutritive values of peanuts; protein quality.
• Effect of heat upon the nutritive values of peanuts; riboflavin and pantothenic acid content.
• Excited electron dynamics modeling of warm dense matter.
• Exploring the molecular mechanism for color distinction in humans.
• Fluorinated imidazoles as proton carriers for water-free fuel cell membranes.
• Genes influencing milk production traits predominantly affect one of four biological pathways.
• Health is an industry.
• How head-hunters track down the winners for science's top jobs.
• Mechanism of Ru(II)-catalyzed olefin insertion and C-H activation from quantum chemical studies.
• Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size.
• Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site.
• Prediction of the 3D structure of FMRF-amide neuropeptides bound to the mouse MrgC11 GPCR and experimental validation.
• Substituent effects and nearly degenerate transition states: rational design of substrates for the tandem Wolff-Cope reaction.
• The conservation of heat in dwelling houses.
• The impact of haemophilia on the success of total hip arthroplasty.
• The inner-sphere process in the enantioselective Tsuji allylation reaction with (S)-t-Bu-phosphinooxazoline ligands.
• The isomerization equilibrium between cis and trans chloride ruthenium olefin metathesis catalysts from quantum mechanics calculations.
• The number of loci that affect milk production traits in dairy cattle.
• The working of joint consultative committees.
• Threshold crack speed controls dynamical fracture of silicon single crystals.
• Traumatic retroperitoneal hematoma illustrated on Tc-99m methylene diphosphonate bone scintigraphy in a patient presenting with a fall.
• Unraveling the Wacker oxidation mechanisms.
• Wax inhibition by comb-like polymers: support of the incorporation-perturbation mechanism from molecular dynamics simulations.
• What are the best treatments for early chronic kidney disease?: A Background Paper prepared for the UK Consensus Conference on Early Chronic Kidney Disease.