Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Research Abstract Details 

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Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Abstract Text:

W S Pratt,S Crawley,J Hicks,J Ho,M Nash,Y S Kim,J R Gum,D M Swallow,

The MUC3 gene encodes a transmembrane mucin-type glycoprotein. A number of consistent single nucleotide changes were observed in different MUC3 cDNAs from a single individual, suggesting the presence of at least three different transcripts per individual. This transcript heterogeneity is due both to the existence of a second copy of the MUC3 gene and to allelic changes. Sequencing of the second MUC3 shows that it has the same C-terminal domain and intron/exon structure as the previously described MUC3. The tandem repeat domain has the same amino acid consensus sequence but shows more substitutions. The unique exonic sequences range from 94 to 100% identity at the nucleotide level and correspondingly few amino acid changes have been identified. The introns show around 95% identity. We propose to name this second gene MUC3B, MUC3A being reserved for the first MUC3 gene. MUC3B, like MUC3A, is expressed in intestine and Caco-2 cells.

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Publishing Authors By Initials

WS Pratt,S Crawley,J Hicks,J Ho,M Nash,YS Kim,JR Gum,DM Swallow,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemical and biophysical research communication

VOLUME: 275

Page Numbers: 916-23

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 7

MONTH: Sep

YEAR: 2000

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.

AFFILIATION: MRC Human Biochemical Genetics Unit, University College London, 4 Stephenson Way, London, NW1 2HE, United Kingdom.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA 24321

ACRONYM: CA

MEDLINETA: Biochem Biophys Res Commun

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