Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology.

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology. Research Abstract Details 

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Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology. Abstract Text:

Meizhang Li,Richard M Ransohoff,

Chemotactic cytokines (chemokines) have been traditionally defined as small (10-14kDa) secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are constitutively expressed in the central nervous system (CNS) where immune activities are under stringent control. Why and how the CNS uses the chemokine system to carry out its complex physiological functions has intrigued neurobiologists. Here, we focus on chemokine CXCL12 and its receptor CXCR4 that have been widely characterized in peripheral tissues and delineate their main functions in the CNS. Extensive evidence supports CXCL12 as a key regulator for early development of the CNS. CXCR4 signaling is required for the migration of neuronal precursors, axon guidance/pathfinding and maintenance of neural progenitor cells (NPCs). In the mature CNS, CXCL12 modulates neurotransmission, neurotoxicity and neuroglial interactions. Thus, chemokines represent an inherent system that helps establish and maintain CNS homeostasis. In addition, growing evidence implicates altered expression of CXCL12 and CXCR4 in the pathogenesis of CNS disorders such as HIV-associated encephalopathy, brain tumor, stroke and multiple sclerosis (MS), making them the plausible targets for future pharmacological intervention.

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology. Publishing Authors By Initials

M Li,RM Ransohoff,

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Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Progress in neurobiology

VOLUME: 84

Page Numbers: 116-31

Journal Abbreviation: Prog. Neurobiol.

ISSN: 0301-0082

DAY: 26

MONTH: 11

YEAR: 2007

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology.

AFFILIATION: Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Country: England

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MEDLINETA: Prog Neurobiol

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