Multiple pathways involved in the biosynthesis of anandamide.

Multiple pathways involved in the biosynthesis of anandamide. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Multiple pathways involved in the biosynthesis of anandamide. Abstract Text:

Jie Liu,Lei Wang,Judith Harvey-White,Bill X Huang,Hee-Yong Kim,Serge Luquet,Richard D Palmiter,Gerald Krystal,Ravi Rai,Anu Mahadevan,Raj K Razdan,George Kunos,

Endocannabinoids, including anandamide (arachidonoyl ethanolamide) have been implicated in the regulation of a growing number of physiological and pathological processes. Anandamide can be generated from its membrane phospholipid precursor N-arachidonoyl phosphatidylethanolamine (NAPE) through hydrolysis by a phospholipase D (NAPE-PLD). Recent evidence indicates, however, the existence of two additional, parallel pathways. One involves the sequential deacylation of NAPE by alpha,beta-hydrolase 4 (Abhd4) and the subsequent cleavage of glycerophosphate to yield anandamide, and the other one proceeds through phospholipase C-mediated hydrolysis of NAPE to yield phosphoanandamide, which is then dephosphorylated by phosphatases, including the tyrosine phosphatase PTPN22 and the inositol 5' phosphatase SHIP1. Conversion of synthetic NAPE to AEA by brain homogenates from wild-type and NAPE-PLD(-/-) mice can proceed through both the PLC/phosphatase and Abdh4 pathways, with the former being dominant at shorter (<10min) and the latter at longer (60min) incubations. In macrophages, the endotoxin-induced synthesis of anandamide proceeds uniquely through the phospholipase C/phosphatase pathway.

Multiple pathways involved in the biosynthesis of anandamide. Publishing Authors By Initials

J Liu,L Wang,J Harvey-White,BX Huang,HY Kim,S Luquet,RD Palmiter,G Krystal,R Rai,A Mahadevan,RK Razdan,G Kunos,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Multiple pathways involved in the biosynthesis of anandamide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuropharmacology

VOLUME: 54

Page Numbers: 1-7

Journal Abbreviation: Neuropharmacology

ISSN: 0028-3908

DAY: 6

MONTH: 06

YEAR: 2007

Multiple pathways involved in the biosynthesis of anandamide. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 236217

Multiple pathways involved in the biosynthesis of anandamide. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Multiple pathways involved in the biosynthesis of anandamide. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Multiple pathways involved in the biosynthesis of anandamide.

AFFILIATION: Laboratory of Physiologic Studies, NIAAA/NIH, 5625 Fishers Lane, MS-9413, Bethesda, MD 20892-9413, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neuropharmacology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Multiple pathways involved in the biosynthesis of anandamide Related Publications

• Adrenergic receptor research: recent developments.
• Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
• Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
• Mesenteric vasodilation mediated by endothelial anandamide receptors.
• Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations.
• Multiple pathways involved in the biosynthesis of anandamide.
• Paracrine Activation of Hepatic CB(1) Receptors by Stellate Cell-Derived Endocannabinoids Mediates Alcoholic Fatty Liver.
• Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain.
• The endocannabinoid system as an emerging target of pharmacotherapy.