Multiple pathways differentially regulate global oxidative stress responses in fission yeast.

Multiple pathways differentially regulate global oxidative stress responses in fission yeast. Research Abstract Details 

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Multiple pathways differentially regulate global oxidative stress responses in fission yeast. Abstract Text:

Dongrong Chen,Caroline R M Wilkinson,Stephen Watt,Christopher J Penkett,W Mark Toone,Nic Jones, ,

Cellular protection against oxidative damage is relevant to ageing and numerous diseases. We analyzed the diversity of genome-wide gene expression programs and their regulation in response to various types and doses of oxidants in Schizosaccharomyces pombe. A small core gene set, regulated by the AP-1-like factor Pap1p and the two-component regulator Prr1p, was universally induced irrespective of oxidant and dose. Strong oxidative stresses led to a much larger transcriptional response. The mitogen-activated protein kinase (MAPK) Sty1p and the bZIP factor Atf1p were critical for the response to hydrogen peroxide. A newly identified zinc-finger protein, Hsr1p, is uniquely regulated by all three major regulatory systems (Sty1p-Atf1p, Pap1p, and Prr1p) and in turn globally supports gene expression in response to hydrogen peroxide. Although the overall transcriptional responses to hydrogen peroxide and t-butylhydroperoxide were similar, to our surprise, Sty1p and Atf1p were less critical for the response to the latter. Instead, another MAPK, Pmk1p, was involved in surviving this stress, although Pmk1p played only a minor role in regulating the transcriptional response. These data reveal a considerable plasticity and differential control of regulatory pathways in distinct oxidative stress conditions, providing both specificity and backup for protection from oxidative damage.

Multiple pathways differentially regulate global oxidative stress responses in fission yeast. Publishing Authors By Initials

D Chen,CR Wilkinson,S Watt,CJ Penkett,WM Toone,N Jones,J ,

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Multiple pathways differentially regulate global oxidative stress responses in fission yeast. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular biology of the cell

VOLUME: 19

Page Numbers: 308-17

Journal Abbreviation: Mol. Biol. Cell

ISSN: 1059-1524

DAY: 14

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Multiple pathways differentially regulate global oxidative stress responses in fission yeast.

AFFILIATION: *Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, United Kingdom.

Country: United States

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MEDLINETA: Mol Biol Cell

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