Multiple myeloma and renal failure: one center's experience.

Multiple myeloma and renal failure: one center's experience. Research Abstract Details 

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Multiple myeloma and renal failure: one center's experience. Abstract Text:

Renal involvement remains a major complication of multiple myeloma, particularly in advanced disease. A retrospective analysis was performed of the modes of presentation, treatment and outcome of all patients with multiple myeloma treated in our renal unit between 1987 and 1996. Thirty-four patients were identified: in 26 (76%) the diagnosis of myeloma was made only after referral. Light chains were the most common paraprotein in both serum and urine. Twenty-one (62%) patients underwent renal biopsy: myeloma cast nephropathy was the predominant histological finding in 16 cases. Thirty-one (91%) patients had severe renal failure (GFR < 20 mL/min), with 28 (82%) requiring dialysis within 2 weeks of admission. Despite treatment of presumed precipitaing causes of acute deterioration in renal function, only 1 of these 28 patients subsequently became independent of dialysis. Most had advanced stage myeloma: 29 (85%) were Durie-Salmon stage II or III. Hypercalcemia, sepsis and pathological fractures were the principal complications. Median survival overall was 5 months. The main causes of death were withdrawal of renal replacement therapy (overwhelming myeloma, severe debilitation) and sepsis. Nineteen (56%) patients received long-term (> 1 month) renal replacement therapy with a median survival of 8 months. However, five of these (26%) have survived for more than 12 months on dialysis and report a good quality of life.

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Multiple myeloma and renal failure: one center's experience. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Renal failure

VOLUME: 20

Page Numbers: 597-606

Journal Abbreviation: Ren Fail

ISSN: 0886-022X

DAY: 21

MONTH: Jul

YEAR: 1998

Multiple myeloma and renal failure: one center's experience. Information

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LANGUAGE: eng

NlmUniqueID: 8701128

Multiple myeloma and renal failure: one center's experience. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: mortality

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Grant and Affiliation Information for Multiple myeloma and renal failure: one center's experience.

AFFILIATION: Department of Nephrology, Beaumont Hospital, Dublin, Ireland.

Country: UNITED STATES

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MEDLINETA: Ren Fail

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