Multiple-motor based transport and its regulation by Tau.

Multiple-motor based transport and its regulation by Tau. Research Abstract Details 

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Multiple-motor based transport and its regulation by Tau. Abstract Text:

Michael Vershinin,Brian C Carter,David S Razafsky,Stephen J King,Steven P Gross,

Motor-based intracellular transport and its regulation are crucial to the functioning of a cell. Disruption of transport is linked to Alzheimer's and other neurodegenerative diseases. However, many fundamental aspects of transport are poorly understood. An important issue is how cells achieve and regulate efficient long-distance transport. Mounting evidence suggests that many in vivo cargoes are transported along microtubules by more than one motor, but we do not know how multiple motors work together or can be regulated. Here we first show that multiple kinesin motors, working in conjunction, can achieve very long distance transport and apply significantly larger forces without the need of additional factors. We then demonstrate in vitro that the important microtubule-associated protein, tau, regulates the number of engaged kinesin motors per cargo via its local concentration on microtubules. This function of tau provides a previously unappreciated mechanism to regulate transport. By reducing motor reattachment rates, tau affects cargo travel distance, motive force, and cargo dispersal. We also show that different isoforms of tau, at concentrations similar to those in cells, have dramatically different potency. These results provide a well defined mechanism for how altered tau isoform levels could impair transport and thereby lead to neurodegeneration without the need of any other pathway.

Multiple-motor based transport and its regulation by Tau. Publishing Authors By Initials

M Vershinin,BC Carter,DS Razafsky,SJ King,SP Gross,

For similar microtubule-associated proteins: tau proteins research abstracts see: microtubule-associated proteins: tau proteins research

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Multiple-motor based transport and its regulation by Tau. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 87-92

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 26

MONTH: 12

YEAR: 2006

Multiple-motor based transport and its regulation by Tau. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Multiple-motor based transport and its regulation by Tau. Keywords Mesh Terms:

KEYWORDS: tau Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Multiple-motor based transport and its regulation by Tau. Information

Substance Name: Kinesin

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Multiple-motor based transport and its regulation by Tau.

AFFILIATION: Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: 1R01GM070676

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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