Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis.

Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Research Abstract Details 

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Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Abstract Text:

Nelson D ,Eve Marder,

Neuromodulators can change the output of neural circuits. The crustacean cardiac ganglion (CG) drives the contractions of the heart. The CG is a direct target for neurohormones that are released from the pericardial organs and other neuroendocrine sites. In this study, we have characterized for the first time the physiological actions of the peptides red pigment concentrating hormone (RPCH), Cancer borealis tachykinin-related peptide Ia (CabTRP Ia) and allatostatin III type A (AST-3) on the isolated CG of the crab, Cancer borealis. RPCH and CabTRP Ia excited the CG while AST-3 strongly inhibited its motor output. We also studied the actions of other peptides and small molecule transmitters known to be present in C. borealis. Dopamine, serotonin, proctolin, crustacean cardioactive peptide (CCAP), a number of extended FLRFamide peptides, and cholinergic agonists increased the activity of the CG, GABA inhibited the CG, while other substances had little or no significant effect on the CG motor pattern. These results demonstrate, in one species, that the CG is multiply modulated. We suggest that multiple modulators may be important to regulate and coordinate the activity of the heart and other organs in response to external stimuli or the endogenous physiological state.

Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Publishing Authors By Initials

ND ,E Marder,

For similar peptides: oligopeptides research abstracts see: peptides: oligopeptides research

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Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of experimental biology

VOLUME: 210

Page Numbers: 2873-84

Journal Abbreviation: J. Exp. Biol.

ISSN: 0022-0949

DAY: 3

MONTH: Aug

YEAR: 2007

Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 243705

Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Keywords Mesh Terms:

KEYWORDS: Oligopeptides

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis.

AFFILIATION: Volen Center for Complex Systems and Department of Biology, Brandeis University, MS-013, 415 South Street, Waltham, MA 02454, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS17813

ACRONYM: NS

MEDLINETA: J Exp Biol

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