Multiple atresia of the small intestine: a 20-year review.

Multiple atresia of the small intestine: a 20-year review. Research Abstract Details 

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Multiple atresia of the small intestine: a 20-year review. Abstract Text:

BACKGROUND: Multiple intestinal atresia (MIA) presents with a wide spectrum of bowel pathologies. Its treatment is a challenging task since restoration of anatomical continuity of the affected intestine must be balanced against preservation of the intestine's maximal length. MATERIAL AND METHODS: A retrospective analysis of the medical notes of 26 patients with MIA treated over a 20-year period between 1986 - 2006 was undertaken with a special emphasis on the clinical and surgical perspectives. RESULTS: All 26 cases of MIA were sporadic with no familial history. The mean gestational age and birth weight were 36.1 weeks and 2781 g, respectively. Twenty-three of the infants underwent operative repair within the first days of life. Three patients with gastroschisis had a delayed diagnosis of bowel atresia. The number of atresias per patient ranged from 2 to 10. In 24 newborns atresias were confined to the small bowel, with 2 other patients having additional obstruction of the ascending colon. Various combinations of anatomical types of atresias were found, with type I and type III occurring in 19 patients each. Type II was diagnosed in 7 newborns. Surgical management of MIA consisted of one-stage restoration of bowel continuity with multiple anastomoses and/or enteroplasties in 22 patients. Four patients had an enterostomy performed at initial operation. Early and late postoperative complications requiring operative treatment occurred in 8 patients. The duration of parenteral nutrition ranged from 6 days to 20 months, exceeding 100 days in 6 children. The follow-up ranges from 3 months to 16 years. All the patients are alive and are on a full oral diet. CONCLUSION: Clinical observations of sporadic cases of MIA confined to the small bowel lend support to the hypothesis of a vascular incident etiology. One-stage restoration of intestinal continuity with preservation of maximal intestinal length should be the basic principle of any operative management of MIA. Despite a relatively high morbidity related to the primary damage of the fetal intestine, excellent results with 100 % survival rates can be obtained. After taking the differences in pathogenesis, anatomical and histological features, and the prognosis for sporadic and hereditary forms of MIA into account, these two entities should be classified separately in a modified classification of intestinal atresia.

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Multiple atresia of the small intestine: a 20-year review. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pediatric surgery : official j

VOLUME: 18

Page Numbers: 13-8

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ISSN: 0939-7248

DAY: 27

MONTH: Feb

YEAR: 2008

Multiple atresia of the small intestine: a 20-year review. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Multiple atresia of the small intestine: a 20-year review.

AFFILIATION: Department of Pediatric Surgery and Urology, Wroclaw Medical University, Wroclaw, Poland.

Country: Germany

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MEDLINETA: Eur J Pediatr Surg

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