Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome.

Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Research Abstract Details 

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Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Abstract Text:

C ,E M Haacke,J Hu,Y Xuan,M Makki,M E Behen,M Maqbool,O Muzik,D C Chugani,H T Chugani,C Juhász,E M Haacke,J Hu,Y Xuan,M Makki,M E Behen,M Maqbool,O Muzik,D C Chugani,H T Chugani,

BACKGROUND AND PURPOSE: Impaired cortical venous outflow and abnormal deep venous collaterals are common in Sturge-Weber syndrome (SWS), but their relation to brain metabolism and function is poorly understood. In this study, advanced MR imaging techniques, such as susceptibility-weighted imaging (SWI) and diffusion tensor imaging (DTI), were applied in conjunction with positron-emission tomography (PET), to assess cortical and white matter structural abnormalities and their relation to cortical glucose metabolism and cognitive functions in children with unilateral SWS. MATERIALS AND METHODS: Thirteen children (age, 1.5-10.3 years) with unilateral SWS underwent MR imaging with SWI and DTI, glucose metabolism PET, and comprehensive neuropsychologic assessment prospectively. The MR imaging and PET images were coregistered and cortical regions showing decreased glucose metabolism were compared with locations of SWI signal intensity abnormalities, changes in white matter water diffusion, and cognitive functions. RESULTS: SWI detected both cortical abnormalities (n=8) and deep transmedullary veins (n=9), including those in young children with no cortical SWI signal intensity changes. These veins were often located under cortex adjacent to hypometabolic regions. DTI showed abnormal water diffusion both under hypometabolic cortex and in adjacent white matter with collateral veins. Cognitive dysfunction was associated with abnormal water diffusion in the posterior white matter. CONCLUSIONS: Transmedullary venous collaterals can be detected early by SWI and persist in white matter adjacent to damaged cortex in children with SWS. Microstructural white matter damage extends beyond cortical abnormalities and may contribute to cognitive impairment. SWI and DTI can be incorporated into clinical MR imaging acquisitions to objectively assess microstructural abnormalities at different stages of SWS.

Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Publishing Authors By Initials

C ,EM Haacke,J Hu,Y Xuan,M Makki,ME Behen,M Maqbool,O Muzik,DC Chugani,HT Chugani,C Juhász,EM Haacke,J Hu,Y Xuan,M Makki,ME Behen,M Maqbool,O Muzik,DC Chugani,HT Chugani,

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Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJNR. American journal of neuroradiology

VOLUME: 28

Page Numbers: 900-6

Journal Abbreviation:

ISSN: 0195-6108

DAY: 3

MONTH: May

YEAR: 2007

Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: metabolism

Chemical & Substance for Abstract: Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome.

AFFILIATION: Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA. juhasz@pet.wayne.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS041922

ACRONYM: NS

MEDLINETA: AJNR Am J Neuroradiol

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