Multilineage differentiation of human MSC after in utero transplantation.

Multilineage differentiation of human MSC after in utero transplantation. Research Abstract Details 

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Multilineage differentiation of human MSC after in utero transplantation. Abstract Text:

Prenatal transplantation of stem cells is an exciting frontier for the treatment of many congenital diseases. The fetus may be an ideal recipient for stem cells, as it is immunologically immature and has rapidly proliferating cellular compartments that may support the engraftment of transplanted cells. Mesenchymal stem cells (MSC), given their ability to differentiate among multiple lineages, could potentially be used to treat diseases such as osteogenesis imperfecta, muscular dystrophy, and a variety of others that can be diagnosed in utero. We have shown, using a human-sheep in utero xenotransplantation model, that human MSC have the ability to engraft, differentiate into many tissue types, and survive for over 1 year in fetal lamb recipients. This observation warrants further studies of the behavior of MSC following systemic or site-directed transplantation.

Multilineage differentiation of human MSC after in utero transplantation. Publishing Authors By Initials

For similar surgical procedures, operative: transplantation: transplantation, heterologous research abstracts see: surgical procedures, operative: transplantation: transplantation, heterologous research

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Multilineage differentiation of human MSC after in utero transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cytotherapy

VOLUME: 3

Page Numbers: 403-5

Journal Abbreviation: Cytotherapy

ISSN: 1465-3249

DAY: 24

MONTH: 04

YEAR: 2001

Multilineage differentiation of human MSC after in utero transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 100895309

Multilineage differentiation of human MSC after in utero transplantation. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterologous

MESH TERMS: cytology

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Grant and Affiliation Information for Multilineage differentiation of human MSC after in utero transplantation.

AFFILIATION: The Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, PA 19104, USA.

Country: England

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MEDLINETA: Cytotherapy

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