Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions.

Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Research Abstract Details 

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Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Abstract Text:

Clozapine is the prototype of a new class of drugs, referred to as 'atypical antipsychotics'. As a matter of fact, the antipsychotic activity of the drug was not predicted by the first studies with quantitative electroencephalography (QEEG), which actually reported an antidepressant pattern. All previous QEEG studies carried out in healthy subjects used a maximum of four leads, exploring only the posterior quadrants of the scalp. The present article reports findings of a multilead QEEG study carried out in 16 healthy men under resting and vigilance-controlled conditions. Increases in slow (delta, theta, and alpha1) and decreases in fast (alpha2 and beta) activities were found, corresponding to changes described for chlorpromazine-type antipsychotics. These results are compared with those of earlier studies. It is suggested that changes in the beta frequency range vary across subjects, whereas changes in slow and alpha activity are more consistent and critical for defining the QEEG profile of the drug.

Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Publishing Authors By Initials

For similar pharmaceutical preparations: placebos research abstracts see: pharmaceutical preparations: placebos research

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Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychiatry research

VOLUME: 67

Page Numbers: 113-22

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 31

MONTH: Jul

YEAR: 1996

Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Keywords Mesh Terms:

KEYWORDS: Placebos

MESH TERMS: drug effects

Chemical & Substance for Abstract: Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions. Information

Substance Name: Clozapine

Registry Number: 5786-21-0

Grant and Affiliation Information for Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions.

AFFILIATION: Department of Psychiatry, Medical School, University of Naples, Italy. gsilvana@ds.cised.unina.it

Country: IRELAND

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MEDLINETA: Psychiatry Res

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