Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles.

Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles. Research Abstract Details 

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Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles. Abstract Text:

Leslie A Sombers,Marc M Maxson,Andrew G Ewing,Leslie A Sombers,Marc M Maxson,Andrew G Ewing,

AIM: A fraction of vesicles in cells treated with hypertonic solution exhibit multiple dense cores and this is enhanced by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA). These cells were examined to determine if the multicore vesicles are the product of endocytosis or homotypic fusion. METHODS: Electron microscopy was used to determine the number of multicore vesicles and amperometry was used to examine if the multicore vesicles are a competent fraction of the readily releasable pool. RESULTS: In this study, we observed that a substantial portion (15.3%) of large dense core vesicles in PC12 cells contained multiple cores in hypertonic saline loaded with L-DOPA, and amperometric measurements show a bimodal distribution of quantal sizes in treated cells. CONCLUSIONS: The results suggest that the multicored vesicles are formed from homotypic fusion of LCDVs prior to exocytosis.

Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles. Publishing Authors By Initials

LA Sombers,MM Maxson,AG Ewing,LA Sombers,MM Maxson,AG Ewing,

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Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cellular and molecular neurobiology

VOLUME: 27

Page Numbers: 681-5

Journal Abbreviation: Cell. Mol. Neurobiol.

ISSN: 0272-4340

DAY: 12

MONTH: Aug

YEAR: 2007

Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles. Information

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LANGUAGE: eng

NlmUniqueID: 8200709

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Grant and Affiliation Information for Multicore vesicles: hyperosmolarity and L-DOPA induce homotypic fusion of dense core vesicles.

AFFILIATION: Department of Chemistry, The Pennsylvania State University, 104 Chemistry Research Building, University Park, PA 16802-6300, USA.

Country: United States

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MEDLINETA: Cell Mol Neurobiol

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