Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control.

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Abstract Text:

Jaeyeon Kim,Gerald M Saidel,Marco E Cabrera,

A mathematical model of the whole-body metabolism is developed to predict fuel homeostasis during exercise by using hormonal control over cellular metabolic processes. The whole body model is composed of seven tissue compartments: brain, heart, liver, GI (gastrointestinal) tract, skeletal muscle, adipose tissue, and "other tissues". Each tissue compartment is described by dynamic mass balances and major cellular metabolic reactions. The glucagon-insulin controller is incorporated into the whole body model to predict hormonal changes during exercise. Moderate [150 W power output at 60% of peak oxygen consumption (VO(2max))] exercise for 60 min was implemented by increasing ATP utilization rates in heart and skeletal muscle. Arterial epinephrine level was given as an input function, which directly affects heart and skeletal muscle metabolism and indirectly other tissues via glucagon-insulin controller. Model simulations were validated with experimental data from human exercise studies. The exercise induced changes in hormonal signals modulated metabolic flux rates of different tissues in a coordinated way to achieve glucose homeostasis, demonstrating the efficacy of hormonal control over cellular metabolic processes. From experimental measurements of whole body glucose balance and arterial substrate concentrations, this model could predict the dynamic changes of hepatic glycogenolysis and gluconeogenesis, which are not easy to measure experimentally, suggesting the higher contribution of glycogenolysis ( approximately 75%). In addition, it could provide dynamic information on the relative contribution of carbohydrates and lipids for fuel oxidation in skeletal muscle. Model simulations indicate that external fuel supplies from other tissue/organ systems to skeletal muscle become important for prolonged exercise emphasizing the significance of interaction among tissues. In conclusion, this model can be used as a valuable complement to experimental studies due to its ability to predict what is difficult to measure directly, and usefulness to provide information about dynamic behaviors.

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Publishing Authors By Initials

J Kim,GM Saidel,ME Cabrera,

For similar body regions: viscera research abstracts see: body regions: viscera research

PUBMED ID PMID:

MEDLINE DATE:

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of biomedical engineering

VOLUME: 35

Page Numbers: 69-90

Journal Abbreviation:

ISSN: 0090-6964

DAY: 17

MONTH: 11

YEAR: 2006

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 361512

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Keywords Mesh Terms:

KEYWORDS: Viscera

MESH TERMS: physiology

Chemical & Substance for Abstract: Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control.

AFFILIATION: Department of Biomedical Engineering, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: P50 GM 66309

ACRONYM: GM

MEDLINETA: Ann Biomed Eng

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control Related Publications

• A computational model of skeletal muscle metabolism linking cellular adaptations induced by altered loading states to metabolic responses during exercise.
• Computational model of glucose homeostasis during exercise.
• Cutaneous vasculitis following an intradermal tattoo.
• Evaporation and mobility of naphthalene molecules.
• FILARIASIS IN MOUNTAIN PROVIENCE, LUZON, REPUBLIC OF THE PHILIPPINES.
• Guide wire protection for trocar puncture of fluid collections.
• HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo.
• Identification of risk factors for cystic echinococcosis in a peri-urban population of Peru.
• Leprosy in a native-born American from the eastern United States.
• Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise.
• Microwave improved Escherichia coli transformation.
• Model of oxygen transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics.
• Multi-organ system model of O2 and CO2 transport during isocapnic and poikilocapnic hypoxia.
• Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control.
• Multi-scale model of o2 transport and metabolism: response to exercise.
• Muscle oxygen uptake differs from consumption dynamics during transients in exercise.
• Nonlinear dynamics analysis of heart rate variability signals to detect sleep disordered breathing in children.
• Not Available
• OP16.09: Ovarian tumor vascular network assessment by three-dimensional power Doppler angiography (3D-PDA): a reproducibility study.
• On- and Off-transient Oxygen Uptake Kinetics Across Exercise Intensity Domains in Female African-America and Caucasian: 2048: Board #118 May 31 3:30 PM 5:00 PM.
• [Cesarean section with dead fetus.]
• [Current therapeutic criterion in uterine apoplexia (Our experience).]
• [Epidural analgesia with a single injection in labor.]
• [Molar pregnancy; clinical case.]
• [Not Available.]
• [Not Available.]
• [Penicillin-resistant Neisseria gonorrhoeae in Mexico City]
• [Psychiatric and neurological syndromes secondary to typhoid fever in a Peruvian population]
• [Report concerning the article, "A case of afibrinogenemia treated with human fibrinogen", by Jorge Amarales and Ramon Rubio.]
• [The direct agglutination test as an alternative method for the diagnosis of canine and human visceral leishmaniasis.]