Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses.

Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses. Research Abstract Details 

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Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses. Abstract Text:

Xianggang Huang,Lianxing Liu,Li Ren,Chao Qiu,Yanmin Wan,Jianqing Xu,Xianggang Huang,Lianxing Liu,Li Ren,Chao Qiu,Yanmin Wan,Jianqing Xu,Xianggang Huang,Lianxing Liu,Li Ren,Chao Qiu,Yanmin Wan,Jianqing Xu,

An effective vaccine strategy for HIV-1 will probably require the induction and maintenance of both humoral and cellular immunity at mucosal and systemic sites. We tested a new prime-boost approach of intranasal priming with 3x10(6) PFU of replicative recombinant Tiantan vaccinia virus (rTTV) and intramuscular boosting with 100mug DNA plasmid expressing HIV-1 Gag in BALB/c mice along with other strategies. Our data demonstrated that intranasal priming with replicative recombinant Tiantan vaccinia and intramuscular boosting with DNA vaccine raised the highest vaginal IgA and systemic T-cell responses, and modest lung IgA and sera IgG responses among all vaccination regimens; each vaccination regimen generated its own imprint of the most preferential T-cell receptor usage of Vbeta. These results demonstrate that the combination of intranasal priming with replicative recombinant Tiantan vaccinia and intramuscular boosting with DNA vaccine is a preferable regimen for induction of both T-cell and humoral immune responses at mucosal and systemic sites.

Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses. Publishing Authors By Initials

X Huang,L Liu,L Ren,C Qiu,Y Wan,J Xu,X Huang,L Liu,L Ren,C Qiu,Y Wan,J Xu,X Huang,L Liu,L Ren,C Qiu,Y Wan,J Xu,

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Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 25

Page Numbers: 8874-84

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 24

MONTH: 09

YEAR: 2007

Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses.

AFFILIATION: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), China CDC, Beijing, China.

Country: Netherlands

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MEDLINETA: Vaccine

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