Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals.

Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Research Abstract Details 

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Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Abstract Text:

J A Voynow,D M Selby,M C Rose,

The early pathogenic events in cystic fibrosis (CF) include colonization of Pseudomonas in the lung, airway inflammation, and mucus hypersecretion with airway obstruction. The primary mechanisms leading to chronic infection and inflammation are not well understood. One possible explanation for this cascade of events is increased or altered expression of one or more mucin (MUC) genes by CF cells in the respiratory tract. We compared expression levels of three mucin genes, MUC1, MUC2, and MUC5/5AC, known to be expressed in the respiratory tract of CF, allergic rhinitis, and normal individuals. Mucin transcript levels in nasal epithelial cells free from inflammation were quantitated by an MUC mRNA slot-blot method. This study revealed three major findings: (1) MUC5/5AC mRNA was expressed at five- to tenfold greater levels than MUC2 or MUC1 for all subjects. (2) MUC2 mRNA levels were similar among all subject groups. (3) In CF subjects, there was a trend toward reduced MUC5/5AC expression. When normalized to the levels of MUC2 expression in individual specimens, MUC5/5AC expression was reduced significantly in CF cells compared with normal cells. These data suggest that mucin gene expression is altered in noninflamed CF nasal cells.

Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Publishing Authors By Initials

JA Voynow,DM Selby,MC Rose,

For similar respiratory tract diseases: nose diseases: rhinitis: rhinitis, allergic, perennial research abstracts see: respiratory tract diseases: nose diseases: rhinitis: rhinitis, allergic, perennial research

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Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Lung

VOLUME: 176

Page Numbers: 345-54

Journal Abbreviation: Lung

ISSN: 0341-2040

DAY: 30

MONTH: 11

YEAR: 1998

Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7701875

Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Keywords Mesh Terms:

KEYWORDS: Rhinitis, Allergic, Perennial

MESH TERMS: pathology

Chemical & Substance for Abstract: Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals.

AFFILIATION: Department of Pediatrics, George Washington University School of Medicine, Washington, D.C. 20010, USA.

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: R29 HL50694

ACRONYM: HL

MEDLINETA: Lung

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