MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Research Abstract Details 

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MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Abstract Text:

Cystic fibrosis (CF) is characterized by progressive airway obstruction. Although it has been postulated that this is due in part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions. We used confocal microscopy to assess the amount of mucin-like glycoprotein and DNA in CF sputum and found more mucin in bronchitis sputum and a much greater amount of DNA in CF sputum. We then used antibodies to MUC5AC and MUC5B with Western gels and dot-blot to quantify mucin in sputum from 12 patients with CF and 11 subjects without lung disease. There was a 70% decrease in MUC5B and a 93% decrease in MUC5AC in CF sputum (P < 0.005 for both). We conclude that the vol/vol concentration of MUC5AC and MUC5B are decreased in the CF airways relative to normal mucus. This may be due to a relative increase in other components of sputum in the CF airway or to a primary defect in mucin secretion in CF.

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Publishing Authors By Initials

For similar respiratory system: respiratory mucosa research abstracts see: respiratory system: respiratory mucosa research

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MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of respiratory cell and molecular

VOLUME: 31

Page Numbers: 86-91

Journal Abbreviation: Am. J. Respir. Cell Mol. Biol.

ISSN: 1044-1549

DAY: 26

MONTH: 02

YEAR: 2004

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Information

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LANGUAGE: eng

NlmUniqueID: 8917225

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Keywords Mesh Terms:

KEYWORDS: Respiratory Mucosa

MESH TERMS: secretion

Chemical & Substance for Abstract: MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.

AFFILIATION: Department of Pulmonary Medicine, Philipps-University Marburg, Germany.

Country: United States

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MEDLINETA: Am J Respir Cell Mol Biol

REFSOURCE: Am J Respir Cell Mol Biol. 2005 Mar;32(3

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