MUC2 mucin gene expression in the nose and maxillary sinus.

MUC2 mucin gene expression in the nose and maxillary sinus. Research Abstract Details 

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MUC2 mucin gene expression in the nose and maxillary sinus. Abstract Text:

K Takeuchi,A Yuta,Y Sakakura,

PURPOSE: The MUC2 gene encodes the core protein of a mucin expressed in the intestine and lower airway. The purpose of this study is to examine if the MUC2 gene is expressed in the nose and maxillary sinus. MATERIALS AND METHODS: A Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) were performed. For the Northern blot analysis, RNAs were extracted from maxillary mucosae and nasal polyps of patients with chronic sinusitis and from the inferior turbinates of a nasal allergy patient. For RT-PCR, RNAs were extracted from 10 patients with chronic sinusitis, 4 patients with allergic rhinitis, 2 patients with hypertrophic rhinitis, and 6 volunteers with normal nasal mucosa. RESULTS: Hybridization of the Northern blot with SMUC41 (a part of MUC2) cDNA probe showed clear bands in 2 of the 3 samples. In RT-PCR, the first round of amplification (35 cycles) failed to give any bands, but the additional 30 cycles with internal primers gave bands in 6 of 22 samples. CONCLUSIONS: These results indicate that MUC2 mucin gene is expressed in the nose and paranasal sinus. This two-round RT-PCR method will be useful for analysis of MUC2 mucin gene expression using relatively small amount of RNA.

MUC2 mucin gene expression in the nose and maxillary sinus. Publishing Authors By Initials

K Takeuchi,A Yuta,Y Sakakura,

For similar musculoskeletal system: skeleton: bone and bones: skull: facial bones: turbinates research abstracts see: musculoskeletal system: skeleton: bone and bones: skull: facial bones: turbinates research

PUBMED ID PMID:

MEDLINE DATE: 1995 Nov-Dec

MUC2 mucin gene expression in the nose and maxillary sinus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of otolaryngology

VOLUME: 16

Page Numbers: 391-5

Journal Abbreviation: Am J Otolaryngol

ISSN: 0196-0709

DAY: 30

MONTH: 11

YEAR: 2007

MUC2 mucin gene expression in the nose and maxillary sinus. Information

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LANGUAGE: eng

NlmUniqueID: 8000029

MUC2 mucin gene expression in the nose and maxillary sinus. Keywords Mesh Terms:

KEYWORDS: Turbinates

MESH TERMS: metabolism

Chemical & Substance for Abstract: MUC2 mucin gene expression in the nose and maxillary sinus. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for MUC2 mucin gene expression in the nose and maxillary sinus.

AFFILIATION: Department of Otorhinolaryngology Mie University School of Medicine, Japan.

Country: UNITED STATES

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MEDLINETA: Am J Otolaryngol

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