MUC1, MUC2 and MUC5AC expressions in cardiac myxoma.

MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Research Abstract Details 

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MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Abstract Text:

Pao-Hsien Chu,Shih-Ming Jung,Ta-Sen Yeh,Hsin-Chiung Lin,Jaw-Ji Chu,

BACKGROUND: Cardiac myxoma, the most common primary tumor of the heart, has a variable clinical presentation and immunohistochemical profile. An abundant mucopolysaccharidic matrix exists, including mucin, within cardiac myxoma. This investigation first reports the expressions of mucin genes in cardiac myxoma. METHODS: A retrospective study was conducted between December 1976 and February 2003, comprising 101 consecutive patients with cardiac myxoma who were treated with surgical excision. Detailed clinical parameters also were reviewed. Mucin genes, namely MUC1, MUC2 and MUC5AC, were studied immunohistochemically in 47 randomly selected patients. RESULTS: The study group contained 57 (57%) women and 44 (43%) men, with a mean age of 38+/-21 years. Their presentations included: asymptomatic (41%), dyspnea (35%), stroke (23%), chest pain (7%), fever (6%), syncope (5%) and tricuspid regurgitation (70%). The sample included 90 myxoma located in the left atrium, 3 (3%) recurrent myxoma and 8 (8%) myxoma not located in the left atrium. The myxoma did not differ with location or clinical event in terms of pathological scores, such as vascular proliferation, inflammation, cellularity, hyaline, calcification and thrombosis. Cardiac myxoma is characterized by excessive mucus secretion. Expression of membrane-associated MUC1 was considerably higher than that of the secreted mucins, MUC2 and MUC5AC (P<0.05). Furthermore, expression of MUC5AC is related to lesser embolism (P<0.05). CONCLUSIONS: This work first examined the immunohistochemical expression of mucin (MUC1, MUC2 and MUC5AC) in cardiac myxoma. This investigation then showed that the expression of representative membrane-associated mucin, MUC1, and/or secretory mucins, MUC2 and MUC5AC, in cardiac myxoma was associated with important tumor clinicopathological characteristics. Moreover, MUC5AC appears related to lesser embolism. This approach can help distinguish the potential roles of secretory mucins versus membrane-associated mucins in the development of cardiac myxoma.

MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Publishing Authors By Initials

PH Chu,SM Jung,TS Yeh,HC Lin,JJ Chu,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research

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MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Virchows Archiv : an international journal of path

VOLUME: 446

Page Numbers: 52-5

Journal Abbreviation: Virchows Arch.

ISSN: 0945-6317

DAY: 26

MONTH: 11

YEAR: 2004

MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Information

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LANGUAGE: eng

NlmUniqueID: 9423843

MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Keywords Mesh Terms:

KEYWORDS: Retrospective Studies

MESH TERMS: pathology

Chemical & Substance for Abstract: MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for MUC1, MUC2 and MUC5AC expressions in cardiac myxoma.

AFFILIATION: The First Cardiovascular Division, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, 199 Tun-Hwa North Road, 105 Taipei, Taiwan. pchu@adm.cgmh.org.tw

Country: Germany

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MEDLINETA: Virchows Arch

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