MUC1 is involved in trophoblast transendothelial migration.

MUC1 is involved in trophoblast transendothelial migration. Research Abstract Details 

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MUC1 is involved in trophoblast transendothelial migration. Abstract Text:

Twanda L Thirkill,Tim Cao,Michael Stout,Thomas N Blankenship,Abdul Barakat,Gordon C Douglas,

The factors that regulate trophoblast invasion of the uterine vasculature are incompletely understood. In this paper we show that macaque trophoblasts express the mucin, MUC1, and that it is involved in trophoblast-endothelial interaction. Immunocytochemistry, Western blotting and RT-PCR analyses confirmed that MUC1 was expressed by isolated early gestation macaque trophoblasts. MUC1 was also detected in endovascular trophoblasts in sections of placental-decidual tissue during early gestation. A blocking antibody against MUC1 reduced trophoblast adhesion to uterine endothelial cells and also blocked trophoblast transendothelial migration. MUC1 is known to bind to Intercellular Adhesion Molecule-1 (ICAM-1) in other systems. Incubation in the presence of a blocking antibody against Intercellular Adhesion Molecule-1 (ICAM-1) or recombinant ICAM-1 modestly, but significantly, reduced transendothelial trophoblast migration. These results are consistent with the idea that MUC1 is involved in trophoblast adhesion to uterine endothelial cells and in trophoblast transendothelial migration.

MUC1 is involved in trophoblast transendothelial migration. Publishing Authors By Initials

TL Thirkill,T Cao,M Stout,TN Blankenship,A Barakat,GC Douglas,

For similar cells: trophoblasts research abstracts see: cells: trophoblasts research

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MEDLINE DATE:

MUC1 is involved in trophoblast transendothelial migration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochimica et biophysica acta

VOLUME: 1773

Page Numbers: 1007-14

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 20

MONTH: 04

YEAR: 2007

MUC1 is involved in trophoblast transendothelial migration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

MUC1 is involved in trophoblast transendothelial migration. Keywords Mesh Terms:

KEYWORDS: Trophoblasts

MESH TERMS: metabolism

Chemical & Substance for Abstract: MUC1 is involved in trophoblast transendothelial migration. Information

Substance Name: Intercellular Adhesion Molecule-1

Registry Number: 126547-89-5

Grant and Affiliation Information for MUC1 is involved in trophoblast transendothelial migration.

AFFILIATION: Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616-8643, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: R01HL068035-01A1

ACRONYM: HL

MEDLINETA: Biochim Biophys Acta

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