MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.

MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Research Abstract Details 

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MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Abstract Text:

J A Jarrard,R I Linnoila,H Lee,S M Steinberg,H Witschi,E Szabo,

Abnormalities in mucin-type glycoprotein expression have been documented in a variety of cancers, identifying these molecules as targets for immunologically based therapies and prognostic/diagnostic assays. We examined the expression of the membrane-bound MUC1 mucin in normal, histologically atypical, and neoplastic lung to determine its potential contribution to lung carcinogenesis. In vivo, intense MUC1 immunoreactivity was present in normal type II pneumocytes as well as in a range of atypical lesions derived from type II cells and >60% of primary and metastatic non-small cell lung cancers. Expression was not associated with altered survival, although it was highly correlated with the adenocarcinoma histology. A carcinogenesis model using 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone-exposed hamsters revealed that MUC1 mRNA increased prior to the histological appearance of tumors. In vitro studies using MUC1 expressing non-small cell lung cancer cell lines revealed that differentiation away from a type II cell lineage was associated with dramatic down-regulation of MUC1. We propose that MUC1 is a powerful new marker for the type II pneumocyte cell lineage that allows us to follow the type II pneumocyte lineage during the process of lung carcinogenesis.

MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Publishing Authors By Initials

JA Jarrard,RI Linnoila,H Lee,SM Steinberg,H Witschi,E Szabo,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 58

Page Numbers: 5582-9

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Dec

YEAR: 1998

MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis. Information

Substance Name: Histone Deacetylases

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.

AFFILIATION: Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Rockville, Maryland 20850, USA.

Country: UNITED STATES

AGENCY: United States NIEHS

GRANT: ES-05707

ACRONYM: ES

MEDLINETA: Cancer Res

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