MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss.

MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Research Abstract Details 

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MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Abstract Text:

C Kusakari,K Hozawa,S Koike,M Kyogoku,T Takasaka,

Hearing acuity and inner ear disorders of MRL/lpr mice, bred for the study of autoimmune disease, were examined in comparison to those of BALB/c mice. The auditory brain stem response threshold of 20-week-old MRL/lpr mice was significantly higher than that of BALB/c mice of the same age (p < .01). The pathologic changes of 20-week-old MRL/lpr mice were characterized by the degeneration of intermediate cells, widened intercellular spaces, and immunoglobulin G deposition on the basement membrane of strial blood vessels as well as in the basal infolding of strial marginal cells, which were absent in BALB/c mice. That there were no other evident pathologic findings in the cochlea or middle ear suggests that these changes in the stria vascularis seemed to be responsible for the sensorineural hearing loss of this mouse. The MRL/lpr mouse was thought to be a good experimental model to study the spontaneous sensorineural hearing loss caused by an immune reaction.

MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Publishing Authors By Initials

C Kusakari,K Hozawa,S Koike,M Kyogoku,T Takasaka,

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains research

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MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Annals of otology, rhinology & laryngology. Su

VOLUME: 157

Page Numbers: 82-6

Journal Abbreviation:

ISSN: 0096-8056

DAY: 21

MONTH: Oct

YEAR: 1992

MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Information

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LANGUAGE: eng

NlmUniqueID: 1256156

MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred Strains

MESH TERMS: analysis

Chemical & Substance for Abstract: MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. Information

Substance Name: Immunoglobulin G

Registry Number: 0

Grant and Affiliation Information for MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss.

AFFILIATION: Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.

Country: UNITED STATES

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MEDLINETA: Ann Otol Rhinol Laryngol Suppl

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