MRI of intravenously injected bone marrow cells homing to the site of injured arteries.

MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Abstract Text:

Fabao Gao,Sourav Kar,Jiangyang Zhang,Bensheng Qiu,Piotr Walczak,Malika Larabi,Rong Xue,Emma Frost,Zhiping Qian,Jeff W M Bulte,Xiaoming Yang,

The aim of this study was to test the feasibility of using MRI to detect magnetically labeled, intravenously injected bone marrow (BM) cells homing to injured arteries. In the first phase, BM cells from LacZ-transgenic or green fluorescent protein (GFP)-transgenic mice were transplanted into eight recipient mice. The left femoral arteries of recipient mice were injured using a cuff-constriction or endothelium-damage approach, and the right femoral arteries were uninjured to serve as controls. The location and distribution of migrated LacZ-BM or GFP-BM cells were confirmed with histology. In the second phase, BM-derived cells from LacZ-transgenic mice were labeled with superparamagnetic iron oxide (Feridex) and then transplanted into eight recipient mice with cuff-induced injuries in the left femoral arteries. Migrated Feridex/LacZ-BM cells were monitored in vivo using a 4.7 T MR scanner. Subsequently, high-resolution ex vivo MRI was performed on 9.4 T and 11.7 T. LacZ-positive or GFP-positive cells in the thickened adventitia of the injured arteries were evident on histology. Both in vivo and ex vivo MRI showed larger regions of hypointensity with Feridex-labeled cells at the sites of the injured arteries compared with control arteries (P < 0.01). This study provides initial evidence that may support the potential use of MRI to detect homing of intravenously injected BM cells to injured arteries.

MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Publishing Authors By Initials

F Gao,S Kar,J Zhang,B Qiu,P Walczak,M Larabi,R Xue,E Frost,Z Qian,JW Bulte,X Yang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NMR in biomedicine

VOLUME: 20

Page Numbers: 673-81

Journal Abbreviation:

ISSN: 0952-3480

DAY: 31

MONTH: Nov

YEAR: 2007

MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8915233

MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: MRI of intravenously injected bone marrow cells homing to the site of injured arteries. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for MRI of intravenously injected bone marrow cells homing to the site of injured arteries.

AFFILIATION: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS045062

ACRONYM: NS

MEDLINETA: NMR Biomed

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

MRI of intravenously injected bone marrow cells homing to the site of injured arteries Related Publications

• Application of mucin quantitative competitive reverse transcription polymerase chain reaction in assisting the diagnosis of malignant pleural effusion.
• Aquaporin gene delivery to kidney.
• Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats.
• Late postoperative complication of the foldable lens implantation: opacification of the intraocular lenses.
• Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
• Tissue array technique for p53 expression in human ovarian neoplasms.
• [A case of cerebral schistosomiasis misdiagnosed as brain tumor]
• [Chromosome t (8; 21) and t (15; 17) in a patient with acute myeloid leukemia]
• [Construction of a subtracted cDNA library of differentially expressed genes in human normal liver tissue and primary hepatocellular carcinoma tissue]
• [Control genes of chondrocyte apoptosis in osteoarthritic articular cartilage]
• [Effects of cactus, alove veral, momorcica charantia on reducing the blood glucose of diabetic mice]
• [Force-dependent effects of interleukin-8 gene expression in endothelial cells exposed on fluid shear stress]
• [Human cytomegalovirus inhibits the proliferation of CFU-MK in vitro]
• [Immunorelated pancytopenia]
• [Intro-extro cranial approach treat serious post fronto-orbital fracture deformities]
• [Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study]
• [Patients of severe acute respiratory syndrome with hypoxemia treated by anisodamine]
• [Polylactic acid combined with recombinant human bone morphogenetic protein and basic fibroblast growth factor to repair the mandibular defects in rabbits]
• [Protection on proliferation of intestinal epithelial cells against hypoxia-reoxygenation through recombinant heat shock protein 70 adenovirus transfection]
• [Relationship between the changes of beta2-microglobulin in blood and urine and kidney involvements in children with pneumonia]
• [Research progress on the signal transduction and the molecular regulation of oocyte meiotic maturation]
• [Schistosomiasis investigation at 4 villages of Yangjiayuan during a flood in 1999]
• [Second-line Hycamtin in the treatment of lung cancer]
• [Sequential intensified immunosuppressive therapy combining with hematopoietic growth factors in the treatment of severe aplastic anemia]
• [Seventy degrees lateral decubital intraperiteanal laparoscopic adrenal surgery]
• [Studies on photochemical disinfectant enamelled-ware of toxicity experiments]
• [Study on the transformation from myelodysplastic syndromes into acute leukemias]
• [Surgical management of sacrococcygeal chordomas]
• [The genetic characteristic of HLA-DRB1 locus in the Jiangsu-Zhejiang-Shanghai Han population and a comparison of its frequency distribution with that of other populations]
• [The postburn changes in gastric mucosal blood flow and Na+-K+-ATPase activity and their effects on gastric transmucosal potential difference in severely scalded rats]