MRI estimation of contrast agent concentration in tissue using a neural network approach.

MRI estimation of contrast agent concentration in tissue using a neural network approach. Research Abstract Details 

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MRI estimation of contrast agent concentration in tissue using a neural network approach. Abstract Text:

Hassan Bagher-Ebadian,Tavarekere N Nagaraja,Ramesh Paudyal,Polly Whitton,Swayamprava Panda,Joseph D Fenstermacher,James R Ewing,

Using an MRI T(1) by multiple readout pulses (TOMROP) image set, an adaptive neural network (ANN) was trained to directly estimate the concentration of a contrast agent (CA), gadolinium-bovine serum albumin (Gd-BSA), in tissue. In nine rats implanted with a 9L cerebral tumor, MRI acquisition of TOMROP inversion-recovery data was followed by quantitative autoradiography (QAR) using radioiodinated serum albumin (RISA). QAR autoradiograms were used as a training set for the ANN. Precontrast and 25 min postcontrast TOMROP image sets were shown to the ANN in the form of a physical feature set related to 24 inversion-recovery images; QAR autoradiograms at 30 min after injection of RISA were taken as the training standard for the network. After training and optimization, the ANN produced a map of Gd-BSA concentration [g-moles/liter]. The prediction by the ANN of CA concentration at 25 min after injection was well correlated (r = 0.82, P < 0.0001) with the corresponding autoradiogram's measure of CA concentration.

MRI estimation of contrast agent concentration in tissue using a neural network approach. Publishing Authors By Initials

H Bagher-Ebadian,TN Nagaraja,R Paudyal,P Whitton,S Panda,JD Fenstermacher,JR Ewing,

For similar proteins: albumins: serum albumin: serum albumin, bovine research abstracts see: proteins: albumins: serum albumin: serum albumin, bovine research

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MRI estimation of contrast agent concentration in tissue using a neural network approach. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Magnetic resonance in medicine : official journal

VOLUME: 58

Page Numbers: 290-7

Journal Abbreviation:

ISSN: 0740-3194

DAY: 3

MONTH: Aug

YEAR: 2007

MRI estimation of contrast agent concentration in tissue using a neural network approach. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8505245

MRI estimation of contrast agent concentration in tissue using a neural network approach. Keywords Mesh Terms:

KEYWORDS: Serum Albumin, Bovine

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: MRI estimation of contrast agent concentration in tissue using a neural network approach. Information

Substance Name: gadolinium-bovine serum albumin complex

Registry Number: 0

Grant and Affiliation Information for MRI estimation of contrast agent concentration in tissue using a neural network approach.

AFFILIATION: Department of Neurology, Henry Ford Health System, Detroit, Michigan 48202, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL70023

ACRONYM: HL

MEDLINETA: Magn Reson Med

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