MRI detects myocardial iron in the human heart.

MRI detects myocardial iron in the human heart. Research Abstract Details 

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MRI detects myocardial iron in the human heart. Abstract Text:

Nilesh R Ghugre,Cathleen M Enriquez,Ignacio Gonzalez,Marvin D Nelson,Thomas D Coates,John C Wood,

Iron-induced cardiac dysfunction is a leading cause of death in transfusion-dependent anemia. MRI relaxation rates R2(1/T2) and R2*(1/T2*) accurately predict liver iron concentration, but their ability to predict cardiac iron has been challenged by some investigators. Studies in animal models support similar R2 and R2* behavior with heart and liver iron, but human studies are lacking. To determine the relationship between MRI relaxivities and cardiac iron, regional variations in R2 and R2* were compared with iron distribution in one freshly deceased, unfixed, iron-loaded heart. R2 and R2* were proportionally related to regional iron concentrations and highly concordant with one another within the interventricular septum. A comparison of postmortem and in vitro measurements supports the notion that cardiac R2* should be assessed in the septum rather than the whole heart. These data, along with measurements from controls, provide bounds on MRI-iron calibration curves in human heart and further support the clinical use of cardiac MRI in iron-overload syndromes.

MRI detects myocardial iron in the human heart. Publishing Authors By Initials

NR Ghugre,CM Enriquez,I Gonzalez,MD Nelson,TD Coates,JC Wood,

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MRI detects myocardial iron in the human heart. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Magnetic resonance in medicine : official journal

VOLUME: 56

Page Numbers: 681-6

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ISSN: 0740-3194

DAY: 3

MONTH: Sep

YEAR: 2006

MRI detects myocardial iron in the human heart. Information

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LANGUAGE: eng

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Grant and Affiliation Information for MRI detects myocardial iron in the human heart.

AFFILIATION: Division of Cardiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027-0034, USA.

Country: United States

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MEDLINETA: Magn Reson Med

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