MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage.

MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Research Abstract Details 

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MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Abstract Text:

Elna-Marie Larsson,Paul Sundén,Carl-Gustav Olsson,Jörg Debatin,Andre J Duerinckx,Richard Baum,Dietbert Hahn,Franz Ebner,

OBJECTIVE: The objective of this study was to determine the optimal dose of the iron oxide contrast agent feruglose for contrast-enhanced MR venography of the abdominopelvic and lower extremity veins and to evaluate its safety and tolerability in patients with deep venous thrombosis. SUBJECTS AND METHODS: We enrolled in our study a total of 45 patients at six centers who had lower extremity deep venous thrombosis documented on radiographic venography. Forty-four patients received the study drug; 39 completed the study. Each patient received three sequential IV injections of feruglose at doses of 0.75, 1.25, and 3.0 mg Fe/kg body weight. MR venography at 1.5 T was repeated at three levels after each dose. Safety was evaluated. RESULTS: The agreement between contrast-enhanced MR venography and radiographic venography with regard to deep venous thrombosis above the knee was zero at the lowest dose (0.75 mg Fe/kg body weight), 43% at the dose 2.0 mg Fe/kg body weight, and 49% at the dose 5.0 mg Fe/kg body weight. No significant difference was seen between the two highest doses. The highest cumulative dose provided the greatest diagnostic usefulness score. No serious adverse events occurred. CONCLUSION: The two highest doses of feruglose showed the best agreement between contrast-enhanced MR venography and radiographic venography for deep venous thrombosis above the knee. The safety and tolerability of feruglose were confirmed.

MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Publishing Authors By Initials

EM Larsson,P Sundén,CG Olsson,J Debatin,AJ Duerinckx,R Baum,D Hahn,F Ebner,

For similar cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis: venous thrombosis research abstracts see: cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis: venous thrombosis research

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MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJR. American journal of roentgenology

VOLUME: 180

Page Numbers: 227-32

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Jan

YEAR: 2003

MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7708173

MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Keywords Mesh Terms:

KEYWORDS: Venous Thrombosis

MESH TERMS: radiography

Chemical & Substance for Abstract: MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage.

AFFILIATION: Department of Neuroradiology, Center for Medical Imaging and Physiology, Lund University Hospital, SE-221 85 Lund, Sweden.

Country: United States

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MEDLINETA: AJR Am J Roentgenol

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