MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent.

MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Research Abstract Details 

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MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Abstract Text:

Olaf Saborowski,Gerhard H Simon,Hans-Juergen Raatschen,Michael F Wendland,Yanjun Fu,Tobias Henning,Rick Baehner,Claire Corot,Mei-Hsiu Chen,Heike E Daldrup-Link,Olaf Saborowski,Gerhard H Simon,Hans-Juergen Raatschen,Michael F Wendland,Yanjun Fu,Tobias Henning,Rick Baehner,Claire Corot,Mei-Hsiu Chen,Heike E Daldrup-Link,Olaf Saborowski,Gerhard H Simon,Hans-Juergen Raatschen,Michael F Wendland,Yanjun Fu,Tobias Henning,Rick Baehner,Claire Corot,Mei-Hsiu Chen,Heike E Daldrup-Link,

The purpose of this study was to investigate if the new folate receptor-targeted Gd-chelate P866 may enhance immune-mediated arthritis. A monoarthritis was induced in the right knee of 15 Sprague-Dawley rats. MR imaging of both knees was performed at 2 T before and up to 2 h and 24 h after injection (p.i.) of P866 (n = 3 dose finding study and n = 6, 0.02 mmol Gd/kg), the non-FR targeted P866 analog P1001 (n = 3 at 24 h after P866-administration, 0.02 mmol Gd/kg) or Gd-DOTA (n = 6, 0.1 mmol Gd/kg). Pulse sequences comprised T(1)-SPGR 80 degrees /50 ms/1.7 ms (flip angle/TR/TE) and inversion recovery 10 degrees /3000 ms/1500 ms/50-3050, 10 000 ms (flip angle/TR/TE/TI) sequences. DeltaSI-data and T(1)-relaxation times of arthritic knees and contralateral normal knees were determined. Folate receptor expression was confirmed with histopathology. All three contrast agents showed an initial perfusion effect with significantly higher DeltaSI-data of arthritic knees compared with normal knees (p < 0.05). In addition, P866, but not P1001 or Gd-DOTA, showed a prolonged enhancement of the synovitis. Compared with precontrast values, the T(1)-relaxation times of inflamed synovia were significantly decreased at 2 h p.i. of P866 (p < 0.05), but not P1001 or Gd-DOTA (p > 0.05). Histopathology confirmed the presence of folate receptors in the inflamed joints, but not normal joints. Thus, results suggest a specific accumulation of the folate receptor-targeted Gd-chelate P866 in this arthritis model. Copyright (c) 2007 John Wiley & Sons, Ltd.

MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Publishing Authors By Initials

O Saborowski,GH Simon,HJ Raatschen,MF Wendland,Y Fu,T Henning,R Baehner,C Corot,MH Chen,HE Daldrup-Link,O Saborowski,GH Simon,HJ Raatschen,MF Wendland,Y Fu,T Henning,R Baehner,C Corot,MH Chen,HE Daldrup-Link,O Saborowski,GH Simon,HJ Raatschen,MF Wendland,Y Fu,T Henning,R Baehner,C Corot,MH Chen,HE Daldrup-Link,

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MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Contrast media & molecular imaging

VOLUME: 2

Page Numbers: 72-81

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ISSN: 1555-4317

DAY: 9

MONTH: Mar

YEAR: 2007

MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Information

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LANGUAGE: eng

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AFFILIATION: Department of Radiology, UCSF Medical Center, University of California San Francisco, USA.

Country: United States

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MEDLINETA: Contrast Media Mol Imaging

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