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MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease.

MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease. Research Abstract Details 

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  • MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease. Abstract Text:

    tianming liuTianming Liu,winnie c w chuWinnie C W Chu,geoffrey youngGeoffrey Young,kaiming liKaiming Li,benson h y yeungBenson H Y Yeung,lei guoLei Guo,gene c w manGene C W Man,wynnie w m lamWynnie W M Lam,stephen t c wongStephen T C Wong,jack c y chengJack C Y Cheng,

    PURPOSE: To investigate whether regional brain volumes in adolescent idiopathic scoliosis (AIS) patients differ from matched control subjects as AIS subjects are reported to have poor performance on combined visual and proprioceptive testing and impaired postural balance in previous studies. MATERIALS AND METHODS: Twenty AIS female patients with typical right-convex thoracic curve (age range,11-18 years; mean, 14.1 years) and 26 female controls (mean age, 14.8 years) underwent three-dimensional magnetization prepared rapid acquisition gradient echo (3D-MPRAGE) MR imaging. Volumes of 99 preselected neuroanatomical regions were compared by statistical parametric mapping and atlas-based hybrid warping. RESULTS: Analysis of variance statistics revealed significant mean volumetric differences in 22 brain regions between AIS and controls. Ten regions were larger in AIS including the left frontal gyri and white matter in left frontal, parietal, and temporal regions, corpus callosum and brainstem. Twelve regions were smaller in AIS, including right-sided descending white matter tracts (anterior and posterior limbs of the right internal capsule and the cerebral peduncle) and deep nucleus (caudate), bilateral perirhinal cortices, left hippocampus and amygdala, bilateral precuneus gyri, and left middle and inferior occipital gyri. CONCLUSION: Regional brain volume difference in AIS subjects may help to explain neurological abnormalities in this group. J. Magn. Reson. Imaging 2008. (c) 2008 Wiley-Liss, Inc.

    MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease. Publishing Authors By Initials

    t liuT Liu,wc chuWC Chu,g youngG Young,k liK Li,bh yeungBH Yeung,l guoL Guo,gc manGC Man,ww lamWW Lam,st wongST Wong,jc chengJC Cheng,

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    MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of magnetic resonance imaging : JMRI

    VOLUME: 27

    Page Numbers: 732-6

    Journal Abbreviation:

    ISSN: 1053-1807

    DAY: 3

    MONTH: Apr

    YEAR: 2008

    MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease. Information

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    LANGUAGE: eng

    NlmUniqueID: 9105850

    MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease. Keywords Mesh Terms:

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    AFFILIATION: Functional and Molecular Imaging Center, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: J Magn Reson Imaging

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