Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey.

Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Research Abstract Details 

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Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Abstract Text:

Adam W Jackson,Felicity A Pino,Erica D Wiebe,Andrew D McClellan,

In in vitro brain/spinal cord preparations from larval lamprey, locomotor-like ventral root burst activity can be initiated by pharmacological (i.e., "chemical") microstimulation in several brain areas: rostrolateral rhombencephalon (RLR); dorsolateral mesencephalon (DLM); ventromedial diencephalon (VMD); and reticular nuclei. However, the quality and symmetry of rhythmic movements that would result from this in vitro burst activity have not been investigated in detail. In the present study, pharmacological microstimulation was applied to the above brain locomotor areas in semi-intact preparations from larval lamprey. First, bilateral pharmacological microstimulation in the VMD, DLM, or RLR initiated symmetrical swimming movements and coordinated muscle burst activity that were virtually identical to those during free swimming in whole animals. Unilateral microstimulation in these brain areas usually elicited asymmetrical undulatory movements. Second, with synaptic transmission blocked in the brain, bilateral pharmacological microstimulation in parts of the anterior (ARRN), middle (MRRN), or posterior (PRRN) rhombencephalic reticular nucleus also initiated symmetrical swimming movements and muscle burst activity. Stimulation in effective sites in the ARRN or PRRN initiated higher-frequency locomotor movements than stimulation in effective sites in the MRRN. Unilateral stimulation in reticular nuclei elicited asymmetrical rhythmic undulations or uncoordinated movements. The present study is the first to demonstrate in the lamprey that stimulation in higher-order locomotor areas (RLR, VMD, DLM) or reticular nuclei initiates and sustains symmetrical, well-coordinated locomotor movements and muscle activity. Finally, bilateral stimulation was a more physiologically realistic test of the function of these brain areas than unilateral stimulation.

Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Publishing Authors By Initials

AW Jackson,FA Pino,ED Wiebe,AD McClellan,

For similar musculoskeletal system: muscles research abstracts see: musculoskeletal system: muscles research

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Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neurophysiology

VOLUME: 97

Page Numbers: 3229-41

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 21

MONTH: 02

YEAR: 2007

Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375404

Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Keywords Mesh Terms:

KEYWORDS: Muscles

MESH TERMS: physiology

Chemical & Substance for Abstract: Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey.

AFFILIATION: Division of Biological Sciences, University of Missouri, Columbia, MO 65211-6190, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS-29043

ACRONYM: NS

MEDLINETA: J Neurophysiol

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