Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling.

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Abstract Text:

Catherine Coffinier,Nan Ketpura,Uyen Tran,Douglas Geissert,E M De Robertis,

The Dpp/BMP signaling pathway is highly conserved between vertebrates and invertebrates. The recent molecular characterization of the Drosophila crossveinless-2 (cv-2) mutation by Conley and colleagues introduced a novel regulatory step in the Dpp/BMP pathway (Development 127 (2000) 3945). The CV-2 protein is secreted and contains five cysteine-rich (CR) domains similar to those observed in the BMP antagonist Short gastrulation (Sog) of Drosophila and Chordin (Chd) of vertebrates. The mutant phenotype in Drosophila suggests that CV-2 is required for the differentiation of crossvein structures in the wing which require high Dpp levels. Here we present the mouse and human homologs of the Drosophila cv-2 protein. The mouse gene is located on chromosome 9A3 while the human locus maps on chromosome 7p14. CV-2 is expressed dynamically during mouse development, in particular in regions of high BMP signaling such as the posterior primitive streak, ventral tail bud and prevertebral cartilages. We conclude that CV-2 is an evolutionarily conserved extracellular regulator of the Dpp/BMP signaling pathway.

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Publishing Authors By Initials

C Coffinier,N Ketpura,U Tran,D Geissert,EM De Robertis,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mechanisms of development

VOLUME: 119 Suppl 1

Page Numbers: S179-84

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 30

MONTH: Dec

YEAR: 2002

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9101218

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling.

AFFILIATION: Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mech Dev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling Related Publications

• An electron microscope analysis of nerves infected with the B virus.
• Assay of thyrotropic hormone in human blood.
• Asymmetric mitosis: Unequal segregation of proteins destined for degradation.
• BMP-binding modules in chordin: a model for signalling regulation in the extracellular space.
• Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.
• Cytological and cytochemical bases of thyroid function.
• Endodermal Nodal-related signals and mesoderm induction in Xenopus.
• Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal.
• Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling.
• Neural induction in the absence of organizer in salamanders is mediated by MAPK.
• Postnatal evolution of steroidogenic cells in the chick ovary.
• Proteolytic activity in the physiology, pathology and therapeutics of the thyroid gland.
• The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation.
• The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.
• The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.
• The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.
• Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm.
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [The head inducer Cerberus in a multivalent extracellular inhibitor]