Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping.

Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping. Research Abstract Details 

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Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping. Abstract Text:

Hongrun Yu,David J Baylink,Godfred L Masinde,Runzhi Li,Bay Nguyen,Heather M Davidson,Shizhong Xu,Subburaman Mohan,Hongrun Yu,David J Baylink,Godfred L Masinde,Runzhi Li,Bay Nguyen,Heather M Davidson,Shizhong Xu,Subburaman Mohan,

Development of gene therapies for wound healing will depend on the identification of the genes involved in wound healing and tissue regeneration. Previous quantitative trait loci (QTL) studies in mice using the ear punch model have shown that major QTL exist on chromosome (Chr) 9 for soft tissue regeneration. In this study, we have developed a congenic line that contains the Chr 9 QTL chromosomal region from super healer MRL/MpJ in the genomic background of poor-healing SJL/J. The phenotypic effect of this QTL was confirmed in male mice, where the congenic line has shown significant healing improvement over SJL. Fine mapping of the Chr 9 QTL region with 23 markers at an average distance of 4.2 Mb using a total of 1,564 MRL/MpJ x SJL/J F(2) mice revealed the presence of at least three QTL peaks, implying that three separate loci may contribute to the phenotypic effect of this QTL. Based on the 2-LOD intervals, the total QTL region was confined to a combined length of no more than 28.2 Mb. Application of a Bayesian shrinkage estimation indicated that a major locus was located in a region of just 1.3 Mb.

Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping. Publishing Authors By Initials

H Yu,DJ Baylink,GL Masinde,R Li,B Nguyen,HM Davidson,S Xu,S Mohan,H Yu,DJ Baylink,GL Masinde,R Li,B Nguyen,HM Davidson,S Xu,S Mohan,

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Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Wound repair and regeneration : official publicati

VOLUME: 15

Page Numbers: 922-7

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ISSN: 1067-1927

DAY: 21

MONTH: 11

YEAR: 2007

Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping.

AFFILIATION: Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California, USA.

Country: United States

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MEDLINETA: Wound Repair Regen

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