Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3.

Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3. Research Abstract Details 

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Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3. Abstract Text:

David B Jaffe,Rafael ,David B Jaffe,Rafael ,

Communication between the dentate gyrus (DG) and area CA3 of the hippocampus proper is transmitted via axons of granule cells - the mossy fiber (MF) pathway. In this review we discuss and compare the properties of transmitter release from the MFs onto pyramidal neurons and interneurons. An examination of the anatomical connectivity from DG to CA3 reveals a surprising interplay between excitation and inhibition for this circuit. In this respect it is particularly relevant that the major targets of the MFs are interneurons and that the consequence of MF input into CA3 may be inhibitory or excitatory, conditionally dependent on the frequency of input and modulatory regulation. This is further complicated by the properties of transmitter release from the MFs where a large number of co-localized transmitters, including GABAergic inhibitory transmitter release, and the effects of presynaptic modulation finely tune transmitter release. A picture emerges that extends beyond the hypothesis that the MFs are simply "detonators" of CA3 pyramidal neurons; the properties of synaptic information flow from the DG have more subtle and complex influences on the CA3 network.

Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3. Publishing Authors By Initials

DB Jaffe,R ,DB Jaffe,R ,

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Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Progress in brain research

VOLUME: 163

Page Numbers: 109-805

Journal Abbreviation: Prog. Brain Res.

ISSN: 0079-6123

DAY: 3

MONTH: 09

YEAR: 2007

Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3. Information

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LANGUAGE: eng

NlmUniqueID: 376441

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Grant and Affiliation Information for Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3.

AFFILIATION: Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.

Country: Netherlands

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MEDLINETA: Prog Brain Res

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