Moss bioreactors producing improved biopharmaceuticals.

Moss bioreactors producing improved biopharmaceuticals. Research Abstract Details 

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Moss bioreactors producing improved biopharmaceuticals. Abstract Text:

Eva L Decker,Ralf Reski,Eva L Decker,Ralf Reski,Eva L Decker,Ralf Reski,

Plants may serve as superior production systems for complex recombinant pharmaceuticals. Current strategies for improving plant-based systems include the development of large-scale production facilities as well as the optimisation of protein modifications. While post-translational modifications of plant proteins generally resemble those of mammalian proteins, certain plant-specific protein-linked sugars are immunogenic in humans, a fact that restricts the use of plants in biopharmaceutical production so far. The moss Physcomitrella patens was developed as a contained tissue culture system for recombinant protein production in photo-bioreactors. By targeted gene replacements, moss strains were created with non-immunogenic humanised glycan patterns. These were proven to be superior to currently used mammalian cell lines in producing antibodies with enhanced effectiveness.

Moss bioreactors producing improved biopharmaceuticals. Publishing Authors By Initials

EL Decker,R Reski,EL Decker,R Reski,EL Decker,R Reski,

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Moss bioreactors producing improved biopharmaceuticals. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in biotechnology

VOLUME: 18

Page Numbers: 393-8

Journal Abbreviation: Curr. Opin. Biotechnol.

ISSN: 0958-1669

DAY: 14

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9100492

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AFFILIATION: Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestr. 1, D-79104 Freiburg, Germany.

Country: England

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MEDLINETA: Curr Opin Biotechnol

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