Mortality in women given diethylstilbestrol during pregnancy.

Mortality in women given diethylstilbestrol during pregnancy. Research Abstract Details 

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Mortality in women given diethylstilbestrol during pregnancy. Abstract Text:

L Titus-Ernstoff,R Troisi,E E Hatch,J R Palmer,L A Wise,W Ricker,M Hyer,R Kaufman,K Noller,W Strohsnitter,A L Herbst,P Hartge,R N Hoover,

We used Cox regression analyses to assess mortality outcomes in a combined cohort of 7675 women who received diethylstilbestrol (DES) through clinical trial participation or prenatal care. In the combined cohort, the RR for DES in relation to all-cause mortality was 1.06 (95% CI = 0.98-1.16), and 1.11 (95% CI = 1.02-1.21) after adjusting for covariates and omitting breast cancer deaths. The RR was 1.07 (95% CI = 0.94-1.23) for overall cancer mortality, and remained similar after adjusting for covariates and omitting breast cancer deaths. The RR was 1.27 (95% CI = 0.96-1.69) for DES and breast cancer, and 1.38 (95% CI=1.03-1.85) after covariate adjustment. The RR was 1.82 in trial participants and 1.12 in the prenatal care cohort, but the DES-cohort interaction was not significant (P = 0.15). Diethylstilbestrol did not increase mortality from gynaecologic cancers. In summary, diethylstilbestrol was associated with a slight but significant increase in all-cause mortality, but was not significantly associated with overall cancer or gynaecological cancer mortality. The association with breast cancer mortality was more evident in trial participants, who received high DES doses.

Mortality in women given diethylstilbestrol during pregnancy. Publishing Authors By Initials

L Titus-Ernstoff,R Troisi,EE Hatch,JR Palmer,LA Wise,W Ricker,M Hyer,R Kaufman,K Noller,W Strohsnitter,AL Herbst,P Hartge,RN Hoover,

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MEDLINE DATE:

Mortality in women given diethylstilbestrol during pregnancy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: British journal of cancer

VOLUME: 95

Page Numbers: 107-11

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 20

MONTH: 06

YEAR: 2006

Mortality in women given diethylstilbestrol during pregnancy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370635

Mortality in women given diethylstilbestrol during pregnancy. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Mortality in women given diethylstilbestrol during pregnancy. Information

Substance Name: Diethylstilbestrol

Registry Number: 56-53-1

Grant and Affiliation Information for Mortality in women given diethylstilbestrol during pregnancy.

AFFILIATION: Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA. Titus-Ernstoff@Dartmouth.edu

Country: England

AGENCY: United States NCI

GRANT: CP50531-21

ACRONYM: CP

MEDLINETA: Br J Cancer

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