Morphological features of TMPRSS2-ERG gene fusion prostate cancer.

Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Research Abstract Details 

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Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Abstract Text:

J-M Mosquera,S Perner,F Demichelis,R Kim,M D Hofer,K D Mertz,P L Paris,J Simko,C Collins,T A Bismar,A M Chinnaiyan,M A Rubin,

The TMPRSS2-ETS fusion prostate cancers comprise 50-70% of the prostate-specific antigen (PSA)-screened hospital-based prostate cancers examined to date, making it perhaps the most common genetic rearrangement in human cancer. The most common variant involves androgen-regulated TMPRSS2 and ERG, both located on chromosome 21. Emerging data from our group and others suggests that TMPRSS2-ERG fusion prostate cancer is associated with higher tumour stage and prostate cancer-specific death. The goal of this study was to determine if this common somatic alteration is associated with a morphological phenotype. We assessed 253 prostate cancer cases for TMPRSS2-ERG fusion status using an ERG break-apart FISH assay. Blinded to gene fusion status, two reviewers assessed each tumour for presence or absence of eight morphological features. Statistical analysis was performed to look for significant associations between morphological features and TMPRSS2-ERG fusion status. Five morphological features were associated with TMPRSS2-ERG fusion prostate cancer: blue-tinged mucin, cribriform growth pattern, macronucleoli, intraductal tumour spread, and signet-ring cell features, all with p-values < 0.05. Only 24% (n=30/125) of tumours without any of these features displayed the TMPRSS2-ERG fusion. By comparison, 55% (n=38/69) of cases with one feature (RR=3.88), 86% (n=38/44) of cases with two features (RR=20.06), and 93% (n=14/15) of cases with three or more features (RR=44.33) were fusion positive (p<0.001). To our knowledge, this is the first study that demonstrates a significant link between a molecular alteration in prostate cancer and distinct phenotypic features. The strength of these findings is similar to microsatellite unstable colon cancer and breast cancer involving BRCA1 and BRCA2 mutations. The biological effect of TMPRSS2-ERG overexpression may drive pathways that favour these common morphological features that pathologists observe daily. These features may also be helpful in diagnosing TMPRSS2-ERG fusion prostate cancer, which may have both prognostic and therapeutic implications.

Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Publishing Authors By Initials

JM Mosquera,S Perner,F Demichelis,R Kim,MD Hofer,KD Mertz,PL Paris,J Simko,C Collins,TA Bismar,AM Chinnaiyan,MA Rubin,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of pathology

VOLUME: 212

Page Numbers: 91-101

Journal Abbreviation: J. Pathol.

ISSN: 0022-3417

DAY: 3

MONTH: May

YEAR: 2007

Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 204634

Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: analysis

Chemical & Substance for Abstract: Morphological features of TMPRSS2-ERG gene fusion prostate cancer. Information

Substance Name: TMPRSS2 protein, human

Registry Number: EC 3.4.21.-

Grant and Affiliation Information for Morphological features of TMPRSS2-ERG gene fusion prostate cancer.

AFFILIATION: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115-6110, USA.

Country: England

AGENCY: United States NCI

GRANT: U01 CA113913

ACRONYM: CA

MEDLINETA: J Pathol

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